PHYSICAL DESCRIPTION: White or creamy-white odorless crystalline powder with very bitter taste. pH (5% aqueous solution) 4.0-5.5. pH (10% aqueous solution) 4-5. (NTP, 1992)

none

Decomposes on exposure to air and light. becoming yellow, pink and, finally, violet. Water soluble.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

SYMPTOMS: This compound can cause severe dermatitis in sensitized persons. It may also cause drowsiness, dryness of mouth, nasal congestion, postural hypotension, lowering of body temperature, tachycardia, arrhythmias, agitation, insomnia, depression, miosis and mydriasis, convulsions, photosensitivity, skin rashes, inhibition of ejaculation, obstructive jaundice, chronic constipation, urinary retention, various hematological disorders, allergic reactions, development of purple pigmentation in exposed skin, deposition of pigment in eyes and altered endocrine functions. It reduces the efficiency of heat regulation such that individuals tend to acquire the temperature of the environment. It also reduces salivary and gastric secretion. It may cause extra-pyramidal effects and sedative (neuroletic) effects which cause suppression of spontaneous movement and complex movements while spinal reflexes and unconditioned nociceptive-avoidance behaviors remain intact.

ACUTE/CHRONIC HAZARDS: This compound is an irritant. It may cause dermatitis in sensitized persons. When heated to decomposition it emits very toxic fumes of chlorine, nitrogen oxides and sulfur oxides. (NTP, 1992)

CHLORPROMAZINE HYDROCHLORIDE is incompatible in aqueous solution with sodium salts of barbiturates and other alkaline solutions. Solutions may be stabilized by addition of antioxidants and storing under nitrogen. (NTP, 1992)

• Amines, Phosphines, and Pyridines
• Sulfides, Organic
• Salts, Acidic
• Aryl Halides

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below. More info about absorbents, including situations to watch out for...

• Mineral-Based & Clay-Based Absorbents

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).

RECOMMENDED GLOVE MATERIALS: Permeation Test Results of Diluted Chemical in water (410 mg/mL): If this chemical makes direct contact with your gloves, or if a tear, puncture or hole develops, replace them at once.

Glove Type Model Number Thickness Bkthru Time
PVC Edmont 34-100 0.18 mm 480 min
Latex Ansell 9020-5 0.13 mm 480 min (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

• AMINAZIN HYDROCHLORIDE
• AMINAZIN MONOHYDROCHLORIDE
• AMPLIACTIL MONOHYDROCHLORIDE
• CHLORACTIL
• CHLORAZIN
• 2-CHLORO-10-(3-DIMETHYLAMINOPROPYL)PHENOTHIAZINE MONOHYDROCHLORIDE
• 2-CHLORO-N,N-DIMETHYL-10H-PHENOTHIAZINE-10-PROPANAMINE MONOHYDROCHLORIDE
• CHLOROPROMAZINE HYDROCHLORIDE
• CHLOROPROMAZINE MONOHYDROCHLORIDE
• CHLORPROMAZINE CHLORIDE
• CHLORPROMAZINE HYDROCHLORIDE
• CHLORPROMAZINE MONOHYDROCHLORIDE
• CHLORPROMAZINIUM CHLORIDE
• CONTOMIN
• CPZ
• 10-(3-DIMETHYLAMINOPROPYL)-2-CHLOROPHENOTHIAZINE MONOHYDROCHLORIDE
• HEBANIL
• HIBANIL
• HIBERNAL
• HYBERNAL
• KLORPROMAN
• KLORPROMEX
• LARGACTIL MONOHYDROCHLORIDE
• LARGAKTYL
• MARAZINE
• MEGAPHEN
• NCI-C05210
• NEURAZINE
• NORCOZINE
• PHENOTHIAZINE HYDROCHLORIDE
• PHENOTHIAZINE, 2-CHLORO-10-(3-(DIMETHYLAMINO)PROPYL)-, MONOHYDROCHLORIDE
• PHENOTHIAZINE, 2-CHLORO-10-[3-(DIMETHYLAMINO)PROPYL]-, MONOHYDROCHLORIDE
• PHENOTHIAZINE-10-PROPANAMINE, 2-CHLORO-N,N-DIMETHYL-, MONOHYDROCHLORIDE
• PLEGOMAZIN
• PROMACID
• PROMAPAR
• PROPAPHEN
• PROPAPHENIN HYDROCHLORIDE
• PSYCHOZINE
• 4560 RP HYDROCHLORIDE
• SONAZINE
• TAROCTYL
• THORAZINE
• THORAZINE HYDROCHLORIDE
• TORAZINA
• TRANZINE
• UNITENSEN