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Chemical Datasheet

TRIS(2-CHLOROETHYL)AMINE

6.1 - Poisonous materials
Chemical Identifiers | Hazards | Response Recommendations | Physical Properties | Regulatory Information | Alternate Chemical Names

Chemical Identifiers

CAS Number - Chemical Abstracts Service registry number. Unique identification number assigned to this chemical by the American Chemical Society.

UN/NA Number - The United Nations-North America number (also called UN number or DOT number). 4-digit number identifying an individual chemical or group of chemicals with similar characteristics. Required on shipping papers; often shown on placards or labels. This numbering system was developed by the U.S. Department of Transportation, and then became the UN standard system for classifying hazardous materials.

DOT Hazard Label - U.S. Department of Transportation hazard warning label for the chemical (such as flammable liquid or corrosive). This label must be displayed on shipped packages, railroad tank cars, and tank trucks according to specifications described in 49 CFR 172.

CHRIS Code - 3-letter code used by the U.S. Coast Guard to identify individual chemicals included in its CHRIS (Chemical Hazards Response Information System) manual.

NFPA 704 - Text description of the diamond-shaped placard, which contains codes indicating the level of the chemical's health, flammability, and instability hazards, along with special hazards such as water- and air-reactivity. See a guide to the NFPA diamond.

General Description - Brief description of the chemical's general appearance, behavior, and hazardousness.

List of data sources.
CAS Number UN/NA Number DOT Hazard Label CHRIS Code
  • 555-77-1
  • Poison
none
NFPA 704
data unavailable
General Description
Liquid with faint odor of fish and soap, no odor when pure. Used as a delayed-action casualty military agent.

Hazards

Reactivity Alerts - Special alerts if the chemical is especially reactive (see list of reactivity alerts).

Air & Water Reactions - Special alerts if the chemical reacts with air, water, or moisture.

Fire Hazard - Description of the chemical's fire hazards (such as flammability, explosion risk, or byproducts that may evolve if the chemical is burned).

Health Hazard - Description of the chemical's health hazards (such as toxicity, flammability, or corrosivity).

Reactivity Profile - Description of the chemical's potential reactivity with other chemicals, air, and water. Also includes any other intrinsic reactive hazards (such as polymerizable or peroxidizable).

Reactive Groups - List of reactive groups that the chemical is assigned to, based on its known chemistry. Reactive groups are categories of chemicals that react in similar ways because their chemical structures are similar. Reactive groups are used to predict reactivity when you add a chemical to MyChemicals. Read more about reactive groups.

Potentially Incompatible Absorbents - Absorbents are products that can be used to soak up liquids from spills. However, some absorbents can react with particular chemicals (that is, they are incompatible), so caution should be used in selecting the correct absorbent for your situation. This section provides a list of potentially incompatible absorbents that have been known to react with liquids assigned to one or more of the reactive groups listed on this datasheet. Read more about absorbents, including situations to watch out for.

List of data sources.
Reactivity Alerts
none
Air & Water Reactions
Acts as a strong base in water.
Fire Hazard
When heated to decomposition, it emits chloride and nitrogen oxides. No action on metals or other materials if material is kept dry. Avoid decomposing heat. (EPA, 1998)
Health Hazard
Most toxic of the nitrogen mustards. The median lethal dose for inhalation is 1,500 mg-min/m3; for skin absorption (masked personnel) is 10,000 mg-min/m3. The medium incapacitating dose for eye injury is 200 mg-min/m3; for skin absorption is 2,500 mg-min/m3. (EPA, 1998)
Reactivity Profile
When dissolved in water, it is a strong base; reacts violently with strong oxidants and acids ; attacks copper and copper compounds. [Handling Chemicals Safely 1980. p. 123]; reacts with hypochlorites to give N-chloroamines, some of which are explosives when isolated [Bretherick 1979. p. 108].
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below. More info about absorbents, including situations to watch out for...

Response Recommendations

Isolation and Evacuation - Isolation and evacuation distance recommendations from the Emergency Response Guidebook (ERG).

Firefighting - Response recommendations if the chemical is on fire (or near a fire).

Non-Fire Response - Response recommendations if the chemical isn't on fire (or near a fire).

Protective Clothing - Recommendations for protective gear.

Dupont Tychem® Suit Fabrics - A table of normalized breakthrough times for DuPont Tychem suit fabrics for the chemical, if available.

First Aid - Recommended first aid treatment for people exposed to the chemical.

List of data sources.
Isolation and Evacuation
Excerpt from GUIDE 153 [Substances - Toxic and/or Corrosive (Combustible)]:

As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 2810 datasheet.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2012)
Firefighting
Excerpt from GUIDE 153 [Substances - Toxic and/or Corrosive (Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material.

FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2012)
Non-Fire Response
Avoid inhalation and skin contact. (Non-Specific -- Poisonous Liquid, n.o.s.) Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors.

Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal.

Large spills: dike far ahead of spill for later disposal. (EPA, 1998)
Protective Clothing
For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
Warning: Tris(2-chloroethyl)amine is a strong irritant. Direct contact may result in severe dermal or corneal burns. Effects may be delayed.

Signs and Symptoms of Tris(2-Chloroethyl)amine Exposure: Signs and symptoms of acute exposure to tris(2-chloroethyl)amine may include strong irritation or burning of the eyes, skin, and respiratory tract. Blisters, local phlebitis (irritation of a vein) and erythema (redness of the skin) may be noted. It may cause nausea, vomiting, and severe esophageal or gastrointestinal tract irritation if ingested. Bronchopneumonia, suppression of bone marrow activity, and hearing loss are possible longer term symptoms.

Emergency Life-Support Procedures: Acute exposure to tris(2-chloroethyl)amine may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to tris(2-chloroethyl)amine.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
4. Rush to a health care facility.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to tris(2-chloroethyl)amine.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. Speed in removing material from the eyes is of extreme importance.
5. Wash exposed skin areas thoroughly with soap and water. Speed in removing material from the skin is of extreme importance.
6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
7. Rush to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
2. DO NOT induce vomiting or attempt to neutralize.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.
5. Rush to a health care facility. (EPA, 1998)

Physical Properties

This section contains physical properties, flammability limits, and toxic thresholds for this chemical (see definitions of each property). More property data is available for common chemicals.

See also the Levels of Concern guide for information on AEGLs, ERPGs, PACs, and IDLH values.

List of data sources.
Chemical Formula:
  • C6H12Cl3N
Flash Point: High enough not to interfere with military use of the agent (EPA, 1998)
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point: 25 ° F (EPA, 1998)
Vapor Pressure: 0.0109 mm Hg at 77.0 ° F (EPA, 1998)
Vapor Density (Relative to Air): 7.1 (EPA, 1998)
Specific Gravity: 1.2347 (EPA, 1998)
Boiling Point: 493 ° F at 760.0 mm Hg calculated, decomposes (EPA, 1998)
Molecular Weight: 204.54 (EPA, 1998)
Water Solubility: data unavailable
IDLH: data unavailable

AEGLs (Acute Exposure Guideline Levels)

Interim AEGLs for Nitrogen Mustard-3 (555-77-1)
Exposure Period AEGL-1 AEGL-2 AEGL-3
10 minutes NR 0.13 mg/m3 2.2 mg/m3
30 minutes NR 0.044 mg/m3 0.74 mg/m3
60 minutes NR 0.022 mg/m3 0.37 mg/m3
4 hours NR 0.0056 mg/m3 0.093 mg/m3
8 hours NR 0.0028 mg/m3 0.047 mg/m3
NR = Not recommended due to insufficient data
(NAC/NRC, 2013)

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
Tris(2-chloroethyl)amine; (Nitrogen mustard-3) (555-77-1) 0.002 mg/m3 0.022 mg/m3 0.37 mg/m3
(SCAPA, 2012)

Regulatory Information

This section contains regulatory information from the Title III Consolidated List of Lists (see details about each regulatory field).

List of data sources.
Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
Tris(2-chloroethyl)amine 555-77-1 100 100

(EPA List of Lists, 2012)

Alternate Chemical Names

This section provides a listing of alternate names for this chemical, including trade names and synonyms.