Chemical Datasheet
TOLUENE-2,6-DIISOCYANATE |
|
Chemical Identifiers
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| CAS Number | UN/NA Number | DOT Hazard Label | USCG CHRIS Code |
|---|---|---|---|
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none | |
| NIOSH Pocket Guide | International Chem Safety Card | ||
| none | none | ||
NFPA 704
data unavailable
General Description
Liquid. Used in the manufacture of polyurethane foams, elastomers, and coatings; crosslinking agent for nylon 6. (EPA, 1998)
Hazards
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Hazard fields
include
special hazard alerts
air and water
reactions, fire hazards, health hazards, a reactivity profile, and
details about
reactive groups assignments
and
potentially incompatible absorbents.
The information in CAMEO Chemicals comes from a variety of
data sources.
Reactivity Alerts
none
Air & Water Reactions
No rapid reaction with air. No rapid reaction with water.
Fire Hazard
When heated to decomposition, it emits toxic fumes of nitrogen oxides. Ventilation should be adequate. If polyurethane products are heated, protection against isocyanate release is necessary. Avoid decomposing heat. (EPA, 1998)
Health Hazard
Classified as slightly toxic orally. Probable oral lethal dose in humans is 5 to 15 g/kg or between 1 pint and 1 quart for a 70 (l50 lb.) person. Particularly poisonous when breathed. This is among the most poisonous of isocyanates. Acute and chronic exposures to low concentrations may produce asthmatic attacks. (EPA, 1998)
Reactivity Profile
TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. [Handling Chemcials Safely 1980. p. 907]. Reaction with water to form Carbon Dioxide [Merck 11th ed. 1989].
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents
Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below. More info about absorbents, including situations to watch out for...
- Cellulose-Based Absorbents
- Mineral-Based & Clay-Based Absorbents
- Dirt/Earth
Response Recommendations
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Response Recommendation fields
include isolation and evacuation distances, as well as recommendations for
firefighting, non-fire response, protective clothing, and first aid. The
information in CAMEO Chemicals comes from a variety of
data sources.
Isolation and Evacuation
Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)
Firefighting
Should wear a self-contained breathing apparatus. Move container from fire area if you can do so without risk. Spray cooling water on containers that are exposed to flames until well after fire is out. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.
Should be extinguished with carbon dioxide, dry chemical or inert gas. For large fires fight with water in the form of spray. (EPA, 1998)
Should be extinguished with carbon dioxide, dry chemical or inert gas. For large fires fight with water in the form of spray. (EPA, 1998)
Non-Fire Response
Caution : Mixing with water may result in a violent reaction. Sources of extreme heat or ignition (including sparks or fire) may result in the formation of toxic nitrogen oxide gases.
Decontaminate with a suitable solution such as 10 percent ammonia with alcohol. Keep unnecessary people away, isolate hazard area and deny entry. Stay upwind and keep out of low areas. Ventilate closed spaces before entering them. Shut off ignition sources; no flares, smoking or flames in hazard area. Do not touch spilled material, stop leak if you can do so without risk. Use water spray to reduce vapors.
Small spills: absorb with sand or other noncombustible material and place into containers for later disposal.
Small dry spills: with clean shovel place material into clean dry container and cover; move containers from spill area.
Large spills: dike far ahead of spill for later disposal. (EPA, 1998)
Decontaminate with a suitable solution such as 10 percent ammonia with alcohol. Keep unnecessary people away, isolate hazard area and deny entry. Stay upwind and keep out of low areas. Ventilate closed spaces before entering them. Shut off ignition sources; no flares, smoking or flames in hazard area. Do not touch spilled material, stop leak if you can do so without risk. Use water spray to reduce vapors.
Small spills: absorb with sand or other noncombustible material and place into containers for later disposal.
Small dry spills: with clean shovel place material into clean dry container and cover; move containers from spill area.
Large spills: dike far ahead of spill for later disposal. (EPA, 1998)
Protective Clothing
For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
Warning: Toluene 2,6-diisocyanate is a powerful irritant to the lungs, skin, eyes, and gastrointestinal tract. Caution is advised.
Signs and Symptoms of Acute Toluene 2,6-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,6-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. Cough, laryngitis, chest pain, tightness in the chest, bronchitis, asthma, emphysema, and enlargement of the right side of the heart may also occur. Gastrointestinal effects may include vomiting and abdominal pain. Headache, insomnia, euphoria, depression, anxiety, paranoia, neuroses, and ataxia (incoordination) may also be noted.
Emergency Life-Support Procedures: Acute exposure to toluene 2,6-diisocyanate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to toluene 2,6-diisocyanate.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self- exposure to toluene 2,6-diisocyanate.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. RUSH to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. DO NOT induce vomiting or attempt to neutralize!
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.
5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
7. RUSH to a health care facility. (EPA, 1998)
Signs and Symptoms of Acute Toluene 2,6-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,6-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. Cough, laryngitis, chest pain, tightness in the chest, bronchitis, asthma, emphysema, and enlargement of the right side of the heart may also occur. Gastrointestinal effects may include vomiting and abdominal pain. Headache, insomnia, euphoria, depression, anxiety, paranoia, neuroses, and ataxia (incoordination) may also be noted.
Emergency Life-Support Procedures: Acute exposure to toluene 2,6-diisocyanate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to toluene 2,6-diisocyanate.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self- exposure to toluene 2,6-diisocyanate.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. RUSH to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. DO NOT induce vomiting or attempt to neutralize!
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.
5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
7. RUSH to a health care facility. (EPA, 1998)
Physical Properties
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The
Physical Property fields
include properties such as vapor pressure and
boiling point, as well as explosive limits and
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The information in CAMEO Chemicals comes from a variety of
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Note: For Vapor Density and Specific Gravity, comparing the value to 1.0 can tell you if the chemical will likely sink/rise in air or sink/float in fresh water (respectively). Short phrases have been added to those values below as an aid. However, make sure to also consider the circumstances of a release. The Vapor Density comparisons are only valid when the gas escaping is at the same temperature as the surrounding air itself. If the chemical is escaping from a container where it was pressurized or refrigerated, it may first escape and behave as a heavy gas and sink in the air (even if it has a Vapor Density value less than 1). Also, the Specific Gravity comparisons are for fresh water (density 1.0 g/mL). If your spill is in salt water (density about 1.027 g/mL), you need to adjust the point of comparison. There are some chemicals that will sink in fresh water and float in salt water.
Note: For Vapor Density and Specific Gravity, comparing the value to 1.0 can tell you if the chemical will likely sink/rise in air or sink/float in fresh water (respectively). Short phrases have been added to those values below as an aid. However, make sure to also consider the circumstances of a release. The Vapor Density comparisons are only valid when the gas escaping is at the same temperature as the surrounding air itself. If the chemical is escaping from a container where it was pressurized or refrigerated, it may first escape and behave as a heavy gas and sink in the air (even if it has a Vapor Density value less than 1). Also, the Specific Gravity comparisons are for fresh water (density 1.0 g/mL). If your spill is in salt water (density about 1.027 g/mL), you need to adjust the point of comparison. There are some chemicals that will sink in fresh water and float in salt water.
| Chemical Formula: |
|
Flash Point:
270°F
for a 80% 2,4:20% 2,6 TDI mixture
(EPA, 1998)
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point:
68 to 72°F
for a 80% 2,4:20% 2,6 TDI mixture
(EPA, 1998)
Vapor Pressure:
0.5 mmHg
at 77°F
for a 80% 2,4:20% 2,6 TDI mixture
(EPA, 1998)
Vapor Density (Relative to Air): data unavailable
Specific Gravity:
1.22
at 77°F
for a 80% 2,4:20% 2,6 TDI mixture
(EPA, 1998)
- Denser than water; will sink
Boiling Point:
264 to 271°F
at 18 mmHg
(EPA, 1998)
Molecular Weight:
174.2
(EPA, 1998)
Water Solubility:
Reaction
(NTP, 1992)
Ionization Energy/Potential: data unavailable
IDLH: data unavailable
AEGLs (Acute Exposure Guideline Levels)
| Exposure Period | AEGL-1 | AEGL-2 | AEGL-3 |
|---|---|---|---|
| 10 minutes | 0.02 ppm | 0.24 ppm | 0.65 ppm |
| 30 minutes | 0.02 ppm | 0.17 ppm | 0.65 ppm |
| 60 minutes | 0.02 ppm | 0.083 ppm | 0.51 ppm |
| 4 hours | 0.01 ppm | 0.021 ppm | 0.32 ppm |
| 8 hours | 0.01 ppm | 0.021 ppm | 0.16 ppm |
(NAC/NRC, 2023)
ERPGs (Emergency Response Planning Guidelines)
| Chemical | ERPG-1 | ERPG-2 | ERPG-3 |
|---|---|---|---|
| TDI (Toluene 2,4- (2,6-) Diisocyanate) (584-84-9), (91-08-7) | 0.01 ppm  |
0.15 ppm | 0.6 ppm |
indicates that odor should be detectable near ERPG-1.(AIHA, 2022)
PACs (Protective Action Criteria)
| Chemical | PAC-1 | PAC-2 | PAC-3 |
|---|---|---|---|
| Toluene-2,6-diisocyanate (91-08-7) | 0.02 ppm | 0.083 ppm | 0.51 ppm |
(DOE, 2018)
Regulatory Information
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The
Regulatory Information fields
include information from
the U.S. Environmental Protection Agency's Title III Consolidated List of
Lists,
the U.S. Cybersecurity and Infrastructure Security Agency's Chemical Facility
Anti-Terrorism Standards,
and the U.S. Occupational Safety and Health Administration's
Process Safety Management of Highly Hazardous Chemicals Standard List
(see more about these
data sources).
EPA Consolidated List of Lists
| Regulatory Name | CAS Number/ 313 Category Code |
EPCRA 302 EHS TPQ |
EPCRA 304 EHS RQ |
CERCLA RQ | EPCRA 313 TRI |
RCRA Code |
CAA 112(r) RMP TQ |
|---|---|---|---|---|---|---|---|
| Benzene, 1,3-diisocyanato-2-methyl- | 91-08-7 | 100 pounds | 100 pounds | 100 pounds | X | 10000 pounds | |
| Toluene-2,6-diisocyanate | 91-08-7 | 100 pounds | 100 pounds | 100 pounds | 313 | 10000 pounds |
- "X" indicates that this is a second name for an EPCRA section 313 chemical already included on this consolidated list. May also indicate that the same chemical with the same CAS number appears on another list with a different chemical name.
(EPA List of Lists, 2022)
CISA Chemical Facility Anti-Terrorism Standards (CFATS)
No regulatory information available.OSHA Process Safety Management (PSM) Standard List
No regulatory information available.Alternate Chemical Names
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This section provides a listing of alternate names for this chemical,
including trade names and synonyms.
- BENZENE, 1,3-DIISOCYANATO-2-METHYL-
- BENZENE, 2,6-DIISOCYANATO-1-METHYL-
- 2,6-DIISOCYANATO-1-METHYLBENZENE
- 1,3-DIISOCYANATO-2-METHYLBENZENE
- DIISOCYANATOLUENE
- 2,6-DIISOCYANATOTOLUENE
- HYLENE TCPA
- HYLENE TIC
- HYLENE TM
- HYLENE TM-65
- HYLENE TRF
- ISOCYANIC ACID, 2-METHYL-M-PHENYLENE ESTER
- ISOCYANIC ACID, 2-METHYL-META-PHENYLENE ESTER
- M-TOLYLENE DIISOCYANATE
- META-TOLYLENE DIISOCYANATE
- 2-METHYL-M-PHENYLENE DIISOCYANATE
- 2-METHYL-M-PHENYLENE ISOCYANATE
- 2-METHYL-META-PHENYLENE ISOCYANATE
- NIAX TDI
- NIAX TDI-P
- 2,6-TDI
- TOLUENE 2,6-DIISOCYANATE
- 2,6-TOLUENE DIISOCYANATE
- TOLUENE, 2,6-DIISOCYANATE
- TOLUENE-2,6-DIISOCYANATE
- 2,6-TOLUYLENE DIISOCYANATE
- TOLYLENE 2,6-DIISOCYANATE
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