Yellow oily liquid with a faint characteristic odor. Boiling point 151-153°C. Can reasonably be expected to be a carcinogen. Used as an antioxidant, as an additive for lubricants and as a softener of copolymers. An intermediate in 1,1-dimethylhydrazine production.

none

Water soluble.

When heated to decomposition, it emits toxic fumes of nitrogen oxides. Avoid exposure to ultraviolet light. (EPA, 1998)

Excerpt from NIOSH Pocket Guide for N-Nitrosodimethylamine:

Exposure Routes: Inhalation, skin absorption, ingestion, skin and/or eye contact

Symptoms: Nausea, vomiting, diarrhea, abdominal cramps; headache; fever; enlarged liver, jaundice; decreased liver, kidney, pulmonary function; [potential occupational carcinogen]

Target Organs: Liver, kidneys,lungs

Cancer Site: In animals; lung, kidney, liver & nasal cavity tumors (NIOSH, 2024)

N-NITROSODIMETHYLAMINE is sensitive to exposure to light, especially ultraviolet light. Is stable at room temperature for more than 14 days in aqueous solution at neutral and alkaline pH in the absence of light. Slightly less stable at strongly acid pH at room temperature. Incompatible with strong oxidizing agents. Also incompatible with strong bases. Can be reduced by reducing agents. Incompatible with hydrogen bromide in acetic acid. Also photochemically reactive. (NTP, 1992)

• Azo, Diazo, Azido, Hydrazine, and Azide Compounds
• Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below. More info about absorbents, including situations to watch out for...

• Cellulose-Based Absorbents
• Expanded Polymeric Absorbents

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Avoid inhalation and skin contact. Spills can be absorbed by celite or commercial spill absorbent. After absorbent containing major share of nitrosamine has been picked-up (avoid dusts; do not sweep), surface should be thoroughly cleaned with strong detergent solution. If major spill occurs outside of ventilated area, room should be evacuated and cleanup operation should be carried out by persons equipped with self-contained breathing apparatus. (EPA, 1998)

STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

Excerpt from NIOSH Pocket Guide for N-Nitrosodimethylamine:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin:
• WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.
• DAILY - The worker should wash daily at the end of each work shift, and prior to eating, drinking, smoking, etc.

Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: DAILY - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.

Provide:
• EYEWASH - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection.
• QUICK DRENCH - Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2024)

Normalized Breakthrough Times (in Minutes)

Chemical	CAS Number	State	QS	QC	SL	C3	TF	TP	RC	TK	RF
Dimethyl nitrosamine	62-75-9	Liquid					>480	>480
Methyl N-nitrosomethanamine, N-	62-75-9	Liquid					>480	>480

Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be used around heat, flames, sparks or in potentially flammable or explosive environments. Only...

(DuPont, 2024)

Warning: Nitrosodimethylamine is a suspected human carcinogen, hepatotoxin, and hemorrhagic agent. Caution is advised. Effects may be delayed.

Signs and Symptoms of Nitrosodimethylamine Exposure: Signs and symptoms of acute exposure to nitrosodimethylamine may include myocardial and endocardial hemorrhage after oral exposure. Pulmonary edema and congestion have been noted, as have hepatomegaly (liver enlargement), hepatitis, icterus (jaundice), and ascites (accumulation of serous fluid in the abdomen). Other signs and symptoms may include malaise (body discomfort), vomiting, GI hemorrhage, seizures, and cerebral edema.

Emergency Life-Support Procedures: Acute exposure to nitrosodimethylamine may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Remove victims to fresh air. Emergency personnel should avoid self-exposure to nitrosodimethylamine.
2. Evaluate vital signs including pulse and respiratory rate and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Rush to a health care facility.
4. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to nitrosodimethylamine.
2. Evaluate vital signs including pulse and respiratory rate and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Remove and isolate contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas thoroughly with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
7. Rush to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of nitrosodimethylamine is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4. Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of nitrosodimethylamine may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
4.The following dosages of Ipecac are recommended: Children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to l cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Rush to a health care facility. (EPA, 1998)

• DIMETHYL NITROSAMINE
• DIMETHYLAMINE, N-NITROSO-
• DIMETHYLNITROSAMINE
• DIMETHYLNITROSOAMINE
• DMN
• DMNA
• METHANAMINE, N-METHYL-N-NITROSO-
• N,N-DIMETHYLNITROSAMINE
• N-METHYL-N-NITROSOMETHANAMINE
• N-NITROSO-N,N-DIMETHYLAMINE
• N-NITROSODIMETHYLAMINE
• NITROSODIMETHYLAMINE