Chemical Datasheet
DIPHOSPHORAMIDE, OCTAMETHYL- |
|
Chemical Identifiers
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include common identification numbers, the
NFPA diamond
U.S. Department of Transportation hazard labels, and a general
description of the chemical. The information in CAMEO Chemicals comes
from a variety of
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| CAS Number | UN/NA Number | DOT Hazard Label | USCG CHRIS Code |
|---|---|---|---|
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|
none | |
| NIOSH Pocket Guide | International Chem Safety Card | ||
| none | none | ||
NFPA 704
data unavailable
General Description
Dark brown viscous liquid. Used as an insecticide and as an acaricide. Not registered as a pesticide in the U.S. (EPA, 1998)
Hazards
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The
Hazard fields
include
special hazard alerts
air and water
reactions, fire hazards, health hazards, a reactivity profile, and
details about
reactive groups assignments
and
potentially incompatible absorbents.
The information in CAMEO Chemicals comes from a variety of
data sources.
Reactivity Alerts
none
Air & Water Reactions
No rapid reaction with air. No rapid reaction with water.
Fire Hazard
When heated to decomposition, it can emit highly toxic fumes of oxides of phosphorus. Decomposes when mixed with acid. Hydrolyzed under acid conditions to dimethylamine and orthophosphoric acid. (EPA, 1998)
Health Hazard
Extremely toxic; probable oral lethal dose in humans is 5-50 mg/kg, between 7 drops and 1 teaspoonful for a 150 lb. person. It is highly toxic when inhaled. Material is a cholinesterase inhibitor. It is similar in action to other organophosphorous pesticides in its toxicity. It is slightly less toxic than parathion. Gastrointestinal, neurologic and respiratory symptoms may accompany poisoning with this material. High doses may cause a toxic psychosis similar to acute alcoholism. Persons taking phenobarbital and phenaglycodol together, glutethimide, chlorpromazine hydrochloride, or meprobamate may be at greater risk. These drugs appear to enhance the toxicity of the material markedly. (EPA, 1998)
Reactivity Profile
Organophosphates, such as DIPHOSPHORAMIDE, OCTAMETHYL-, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents
Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below. More info about absorbents, including situations to watch out for...
- Mineral-Based & Clay-Based Absorbents
Response Recommendations
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The
Response Recommendation fields
include isolation and evacuation distances, as well as recommendations for
firefighting, non-fire response, protective clothing, and first aid. The
information in CAMEO Chemicals comes from a variety of
data sources.
Isolation and Evacuation
Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)
Firefighting
(Non-Specific -- Organophosphorus Liquid Pesticides) Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, carbon dioxide, or dry chemical. (EPA, 1998)
Non-Fire Response
Caution : Avoid sources of extreme heat including fire. Diphosphoramide, octamethyl- will liberate toxic phosphorus oxides when heated to decomposition.
(Non-Specific -- Organophosphorus Liquid Pesticides) Use water spray to knock down vapors. Attempt to stop leak if it can be done without hazard. Avoid breathing vapors. Keep upwind. Avoid bodily contact with material. Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. (EPA, 1998)
(Non-Specific -- Organophosphorus Liquid Pesticides) Use water spray to knock down vapors. Attempt to stop leak if it can be done without hazard. Avoid breathing vapors. Keep upwind. Avoid bodily contact with material. Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. (EPA, 1998)
Protective Clothing
For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
Note: Octamethyl diphosphoramide is a cholinesterase inhibitor.
Signs and Symptoms of Acute Diphosphoramide, Octamethyl- [OMPA] Exposure: Acute exposure to OMPA may produce the following signs and symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) and chest pain may be noted. Hypertension (high blood pressure) is not uncommon. Respiratory symptoms include dyspnea, respiratory depression, and respiratory paralysis. Psychosis may occur.
Emergency Life-Support Procedures: Acute exposure to OMPA may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to OMPA.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self- exposure to OMPA.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of OMPA is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4.Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of OMPA may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility. (EPA, 1998)
Signs and Symptoms of Acute Diphosphoramide, Octamethyl- [OMPA] Exposure: Acute exposure to OMPA may produce the following signs and symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) and chest pain may be noted. Hypertension (high blood pressure) is not uncommon. Respiratory symptoms include dyspnea, respiratory depression, and respiratory paralysis. Psychosis may occur.
Emergency Life-Support Procedures: Acute exposure to OMPA may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to OMPA.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self- exposure to OMPA.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of OMPA is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4.Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of OMPA may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility. (EPA, 1998)
Physical Properties
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The
Physical Property fields
include properties such as vapor pressure and
boiling point, as well as explosive limits and
toxic exposure thresholds
The information in CAMEO Chemicals comes from a variety of
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Note: For Vapor Density and Specific Gravity, comparing the value to 1.0 can tell you if the chemical will likely sink/rise in air or sink/float in fresh water (respectively). Short phrases have been added to those values below as an aid. However, make sure to also consider the circumstances of a release. The Vapor Density comparisons are only valid when the gas escaping is at the same temperature as the surrounding air itself. If the chemical is escaping from a container where it was pressurized or refrigerated, it may first escape and behave as a heavy gas and sink in the air (even if it has a Vapor Density value less than 1). Also, the Specific Gravity comparisons are for fresh water (density 1.0 g/mL). If your spill is in salt water (density about 1.027 g/mL), you need to adjust the point of comparison. There are some chemicals that will sink in fresh water and float in salt water.
Note: For Vapor Density and Specific Gravity, comparing the value to 1.0 can tell you if the chemical will likely sink/rise in air or sink/float in fresh water (respectively). Short phrases have been added to those values below as an aid. However, make sure to also consider the circumstances of a release. The Vapor Density comparisons are only valid when the gas escaping is at the same temperature as the surrounding air itself. If the chemical is escaping from a container where it was pressurized or refrigerated, it may first escape and behave as a heavy gas and sink in the air (even if it has a Vapor Density value less than 1). Also, the Specific Gravity comparisons are for fresh water (density 1.0 g/mL). If your spill is in salt water (density about 1.027 g/mL), you need to adjust the point of comparison. There are some chemicals that will sink in fresh water and float in salt water.
| Chemical Formula: |
|
Flash Point: data unavailable
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point:
57 to 68°F
(EPA, 1998)
Vapor Pressure:
0.001 mmHg
at 77°F
(EPA, 1998)
Vapor Density (Relative to Air): data unavailable
Specific Gravity:
1.09
at 77°F
(EPA, 1998)
- Denser than water; will sink
Boiling Point:
248 to 257°F
at 0.5 mmHg
(EPA, 1998)
Molecular Weight:
286.26
(EPA, 1998)
Water Solubility: data unavailable
Ionization Energy/Potential: data unavailable
IDLH: data unavailable
AEGLs (Acute Exposure Guideline Levels)
No AEGL information available.ERPGs (Emergency Response Planning Guidelines)
No ERPG information available.PACs (Protective Action Criteria)
| Chemical | PAC-1 | PAC-2 | PAC-3 |
|---|---|---|---|
| Octamethyldiphosphoramide; (Octamethylpyrophosphoramide, Schradan) (152-16-9) | 0.073 mg/m3 | 0.8 mg/m3 | 4.9 mg/m3 |
(DOE, 2018)
Regulatory Information
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The
Regulatory Information fields
include information from
the U.S. Environmental Protection Agency's Title III Consolidated List of
Lists,
the U.S. Cybersecurity and Infrastructure Security Agency's Chemical Facility
Anti-Terrorism Standards,
and the U.S. Occupational Safety and Health Administration's
Process Safety Management of Highly Hazardous Chemicals Standard List
(see more about these
data sources).
EPA Consolidated List of Lists
| Regulatory Name | CAS Number/ 313 Category Code |
EPCRA 302 EHS TPQ |
EPCRA 304 EHS RQ |
CERCLA RQ | EPCRA 313 TRI |
RCRA Code |
CAA 112(r) RMP TQ |
|---|---|---|---|---|---|---|---|
| Diphosphoramide, octamethyl- | 152-16-9 | 100 pounds | 100 pounds | 100 pounds | P085 |
(EPA List of Lists, 2022)
CISA Chemical Facility Anti-Terrorism Standards (CFATS)
No regulatory information available.OSHA Process Safety Management (PSM) Standard List
No regulatory information available.Alternate Chemical Names
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This section provides a listing of alternate names for this chemical,
including trade names and synonyms.
- BIS(BISDIMETHYLAMINOPHOSPHONOUS) ANHYDRIDE
- BIS(DIMETHYLAMINO)PHOSPHONOUS ANHYDRIDE
- BIS(DIMETHYLAMINO)PHOSPHORIC ANHYDRIDE
- BIS-N,N,N',N'-TETRAMETHYL- PHOSPHORODIAMIDIC ANHYDRIDE
- DIPHOSPHORAMIDE, OCTAMETHYL-
- LETHALAIRE G-59
- OCTAMETHYL
- OCTAMETHYL PYROPHOSPHORTETRAMIDE
- OCTAMETHYL TETRAMIDO PYROPHOSPHATE
- OCTAMETHYL- PYROPHOSPHORAMIDE
- OCTAMETHYLDIPHOSPHORAMIDE
- OCTAMETHYLPYROPHOSPHORAMIDE
- OCTAMETHYLPYROPHOSPHORIC ACID AMIDE
- OCTAMETHYLPYROPHOSPHORIC ACID TETRAMIDE
- OMPA
- OMPACIDE
- OMPATOX
- OMPAX
- PESTOX
- PESTOX 3
- PESTOX III
- PYROPHOSPHORAMIDE, OCTAMETHYL-
- PYROPHOSPHORIC ACID OCTAMETHYLTETRAAMIDE
- PYROPHOSPHORYLTETRAKISDIMETHYLAMIDE
- SCHARADAN
- SCHRADAN
- SYSTAM
- SYSTOPHOS
- SYTAM
- TETRAKISDIMETHYLAMINOPHOSPHONOUS ANHYDRIDE
Web site owner:
Office of Response and Restoration
,
National Ocean Service,
National Oceanic and Atmospheric Administration.
USA.gov.
CAMEO Chemicals version 3.0.0.