PHYSICAL DESCRIPTION: Fine white crystalline powder. Odorless with a slightly bitter taste. Melting point 41-45°C. A 2% solution has pH of 4 to 6. Used medicinally as an antineoplastic agent.

none

Water soluble.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

SYMPTOMS: Symptoms of exposure to this compound may include nausea, vomiting, leukopenia, thrombocytopenia, alopecia and anorexia. Other symptoms may include pigmentation of the skin, oral mucosal ulcerations and sterile hemorrhagic cystitis. It can cause non-specific dermatitis, pigmentation of the nails, regrowth of hair, anemia, hematuria, fibrosis of the ovaries, gonadal suppression resulting in amenorrhea or azoospermia, hemorrhagic colitis and jaundice. It can also cause damage to the hair follicles, dizziness of short duration, transverse ridging of the nails and hepatic toxicity. Secondary neoplasia and nephrotoxicity have been reported. Other symptoms may include irritation of the skin, gastrointestinal disturbances and hepatic dysfunction. High doses over a prolonged period can cause interstitial pulmonary fibrosis. Other symptoms of exposure may include granulocytopenia, myocardial damage, interstitial pneumonia and hypoplasia of all elements of bone marrow. It has been known to cause blurred vision, pulmonary fibrosis, cardiomyopathy and sterility. Fetal abnormalities can occur if ingested while pregnant. Eye contact can cause transient blurring of vision, dry eye syndrome, viral and other keratitis and severe keratoconjunctivitis associated with graft-versus-host disease leading to scarring of the corneas. It may also cause lymphocytopenia.

ACUTE/CHRONIC HAZARDS: This compound is a skin irritant. When heated to decomposition it emits highly toxic fumes of POx, NOx and chloride ion. (NTP, 1992)

CYCLOPHOSPHAMIDE is sensitive to exposure to light (darkens). Also sensitive to oxidation. Aqueous solutions may be kept for a few hours at room temperature, but hydrolysis occurs at temperatures above 86°F. Solutions in DMSO, 95% ethanol or acetone are stable for 24 hours under normal lab conditions. Incompatible with benzyl alcohol. Undergoes both acid and base hydrolysis at extreme pHs (NTP, 1992)

• Amines, Phosphines, and Pyridines
• Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
• Halogenated Organic Compounds

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below. More info about absorbents, including situations to watch out for...

• Mineral-Based & Clay-Based Absorbents

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

Normalized Breakthrough Times (in Minutes)

Chemical	CAS Number	State	QS	QC	SL	C3	TF	TP	RC	TK	RF
Cyclo phosphamide (20 mg/ml)	50-18-0	Liquid		>240

Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be used around heat, flames, sparks or in potentially flammable or explosive environments. Only...

(DuPont, 2023)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

• ASTA
• ASTA B 518
• ASTA B518
• B 518
• 2-(BIS(2-CHLOROETHYL)AMINO)-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE
• 2-(BIS(2-CHLOROETHYL)AMINO)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE
• 1-BIS(2-CHLOROETHYL)AMINO-1-OXO-2-AZA-5-OXAPHOSPHORIDIN
• 1-BIS(2-CHLOROETHYL)AMINO-1-OXO-2-AZA-5-OXAPHOSPHORIDINE
• BIS(2-CHLOROETHYL)PHOSPHAMIDE CYCLIC PROPANOLAMIDE ESTER
• BIS(2-CHLOROETHYL)PHOSPHORAMIDE CYCLIC PROPANOLAMIDE ESTER
• CB 4564
• CLAFEN
• CLAPHENE
• CP
• CPA
• CTX
• CY
• CYCLOPHOSPHAMID
• CYCLOPHOSPHAMIDE
• (-)-CYCLOPHOSPHAMIDE
• (.+-.)-CYCLOPHOSPHAMIDE
• CYCLOPHOSPHAMIDUM
• CYCLOPHOSPHAN
• CYCLOPHOSPHANE
• CYCLOPHOSPHORAMIDE
• CYCLOSTIN
• CYTOPHOSPHAN
• CYTOPHOSPHANE
• CYTOXAN
• 2-(DI(2-CHLOROETHYLAMINO))-1-OXA-3-AZA-2-PHOSPHACYCLOHEXANE 2-OXIDE
• ENDOXAN
• ENDOXAN R
• ENDOXAN-ASTA
• ENDOXANA
• ENDOXANAL
• ENDOXANE
• ENDUXAN
• GENOXAL
• 2H-1,3,2-OXAZAPHOSPHORINE, 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-, 2-OXIDE
• MITOXAN
• N,N-BIS(2-CHLOROETHYL)-N',O-PROPYLENEPHOSPHORIC ACID ESTER DIAMIDE
• N,N-BIS(2-CHLOROETHYL)-N'-(3-HYDROXYPROPYL)PHOSPHORODIAMIDIC ACID INTRAMOL.
• N,N-BIS(2-CHLOROETHYL)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORIN-2-AMINE 2-OXIDE
• N,N-BIS(BETA-CHLOROETHYL)-N',O-PROPYLENEPHOSPHORIC ACID ESTER DIAMIDE
• N,N-BIS(BETA-CHLOROETHYL)-N',O-TRIMETHYLENEPHOSPHORIC ACID ESTER DIAMIDE
• N,N-DI(2-CHLOROETHYL)-N,O-PROPYLENE PHOSPHORIC ACID ESTER DIAMIDE
• NCI-C04900
• NEOSAR
• NSC 26271
• PROCYTOX
• (RS)-CYCLOPHOSPHAMIDE
• SEMDOXAN
• SENDOXAN
• SENDUXAN
• SK 20501
• TETRAHYDRO-N,N-BIS(2-CHLOROETHYL)-2H-1,3,2-OXAZAPHOSPHORIN-2-AMINE 2-OXIDE