DIPHENYLMETHANE-4,4'-DIISOCYANATE

Diphenylmethane-4,4-diisocyanate is a light yellow colored solid. It is not soluble in water. It may be toxic by ingestion, inhalation, or skin absorption. If in a solution it may or may not burn depending on the nature of the material and/or the solvent. It is used to make plastics.

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It is not soluble in water.

Special Hazards of Combustion Products: Toxic vapors are generated when heated.

Behavior in Fire: Solid melts and burns (USCG, 1999)

Breathlessness, chest discomfort, and reduced pulmonary function. (USCG, 1999)

Isocyanates and thioisocyanates, such as DIPHENYLMETHANE-4,4'-DIISOCYANATE, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].

• Isocyanates and Isothiocyanates

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below.

• Cellulose-Based Absorbents
• Mineral-Based & Clay-Based Absorbents
• Dirt/Earth

Excerpt from 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

Excerpt from 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]:

Note: Most foams will react with the material and release corrosive/toxic gases. CAUTION: For Acetyl chloride (UN1717), use CO2 or dry chemical only.

SMALL FIRE: CO2, dry chemical, dry sand, alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. FOR CHLOROSILANES, DO NOT USE WATER; use AFFF alcohol-resistant medium-expansion foam. If it can be done safely, move undamaged containers away from the area around the fire. Avoid aiming straight or solid streams directly onto the product.

FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2020)

Excerpt from 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. A vapor-suppressing foam may be used to reduce vapors. FOR CHLOROSILANES, use AFFF alcohol-resistant medium-expansion foam to reduce vapors. DO NOT GET WATER on spilled substance or inside containers. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas.

SMALL SPILL: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal. (ERG, 2020)

Excerpt from NIOSH Pocket Guide for Methylene bisphenyl isocyanate:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: DAILY - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises. (NIOSH, 2023)

Normalized Breakthrough Times (in Minutes)

Chemical	CAS Number	State	QS	QC	SL	C3	TF	TP	RC	TK	RF
Diphenyl methane diisocyanate, 4,4'-	101-68-8	Solid							>480	>480	>480
Diphenyl methane diisocyanate, 4,4'- (50°C, molten)	101-68-8	Liquid		>480	>480	>480	>480	>480	>480	>480	>480
Methylene diphenyl diisocyanate, 4,4'-	101-68-8	Solid							>480	>480	>480
Methylene diphenyl diisocyanate, 4,4'- (50°C, molten)	101-68-8	Liquid		>480	>480	>480	>480	>480	>480	>480	>480

Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be used around heat, flames, sparks or in potentially flammable or explosive environments. Only...

(DuPont, 2023)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

• BENZENE, 1,1'-METHYLENEBIS(4-ISOCYANATO)- (9CI)
• BIS(1,4-ISOCYANATOPHENYL)METHANE
• BIS(4-ISOCYANATOPHENYL)METHANE
• 4,4'-BIS(ISOCYANATOPHENYL)METHANE
• BIS(P-ISOCYANATOPHENYL)METHANE
• CARADATE 30
• CARWINATE 125 M
• DESMODUR 44
• DI(4-ISOCYANATOPHENYL)METHANE
• 4,4'DIISOCYANATODIPHENYLMETHANE
• 4,4'-DIISOCYANATODIPHENYLMETHANE
• DIPHENYLMETHANE 4,4'-DIISOCYANATE
• DIPHENYLMETHANE DIISOCYANATE
• 4,4'-DIPHENYLMETHANE DIISOCYANATE
• DIPHENYLMETHANE-4,4'-DIISOCYANATE
• DIPHENYLMETHYLENE DIISOCYANATE
• HYLENE M50
• ISOCYANIC ACID, DIPHENYLMETHYLENE ESTER
• ISOCYANIC ACID, METHYLENEDI-P-PHENYLENE ESTER
• ISONATE 125M
• ISONATE 125MF
• MDI
• 4,4'-MDI
• METHYLENE BIS(4-PHENYL ISOCYANATE)
• METHYLENE BISPHENYL ISOCYANATE
• METHYLENE DI-P-PHENYLENE ESTER OF ISOCYANIC ACID
• METHYLENEBIS(4-ISOCYANATOBENZENE)
• 1,1-METHYLENEBIS(4-ISOCYANATOBENZENE)
• METHYLENEBIS(4-PHENYL ISOCYANATE)
• METHYLENEBIS(4-PHENYLENE ISOCYANATE)
• 4,4'-METHYLENEBIS(ISOCYANATOBENZENE)
• METHYLENEBIS(P-PHENYL ISOCYANATE)
• METHYLENEBIS(P-PHENYLENE ISOCYANATE)
• 4,4'-METHYLENEBIS(PHENYL ISOCYANATE)
• METHYLENEBIS(PHENYLISOCYANATE)
• METHYLENEBIS-P-PHENYLENE DIISOCYANATE
• METHYLENEBISPHENYLENE DIISOCYANATE
• 1,1'-METHYLENEBIS[4-ISOCYANATOBENZENE]
• 4,4'-METHYLENEDI(PHENYL ISOCYANATE)
• METHYLENEDI-P-PHENYLENE DIISOCYANATE
• 4,4'-METHYLENEDI-P-PHENYLENE DIISOCYANATE
• METHYLENEDI-P-PHENYLENE ISOCYANATE
• 4,4'-METHYLENEDIPHENYL DIISOCYANATE
• 4,4'-METHYLENEDIPHENYLDIISOCYANATE
• 4,4'-METHYLENEDIPHENYLENE ISOCYANATE
• MULTRATHANE M
• NACCONATE 300
• NCI-C50668
• NOCCONATE 300
• P,P'-DIPHENYLMETHANE DIISOCYANATE
• P,P'-METHYLENEBIS(PHENYL ISOCYANATE)
• VILRATHANE 4300