THIOSEMICARBAZIDE

THIOSEMICARBAZIDE is a white crystalline powder and is odorless. This material is used as a reagent for ketones and certain metals, for photography and as a rodenticide. It is also effective for control of bacterial leaf blight of rice. Not a registered pesticide in the U.S. It is a chemical intermediate for herbicides and a reagent for detection of metals. (EPA, 1998)

none

No rapid reaction with air. No rapid reaction with water.

When heated to decomposition, very toxic fumes of sulfur oxides and nitrogen oxides are emitted. (EPA, 1998)

This material is highly toxic by ingestion. May induce goiter and cause delayed toxic effects in blood and skin. May be mutagenic in human cells. (EPA, 1998)

Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].

• Azo, Diazo, Azido, Hydrazine, and Azide Compounds
• Isocyanates and Isothiocyanates

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below.

• Cellulose-Based Absorbents
• Mineral-Based & Clay-Based Absorbents
• Dirt/Earth

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

(Non-Specific -- Poisonous, Solid, n.o.s.) Stay upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing. Move container from fire area if you can do so without risk.

(Non-Specific -- Poisonous, Solid, n.o.

s) Extinguish with any chemical, carbon dioxide, water spray, fog, or foam. (EPA, 1998)

Avoid skin contact, ingestion or inhalation. (Non-Specific -- Poisonous Solid, n.o.s.) Do not touch spilled material; stop leak if you can do it without risk.

Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal.

Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area.

Large spills: dike far ahead of spill for later disposal. (EPA, 1998)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

No information available.

Warning: Highly toxic by ingestion. May be mutagenic in human cells.

Signs and Symptoms of Thiosemicarbazide Exposure: Signs and symptoms of acute exposure to thiosemicarbazide may include eye and skin irritation, excessive salivation, vomiting, pulmonary edema, pleural effusions, central nervous system stimulation, and seizures.

Emergency Life-Support Procedures: Acute exposure to thiosemicarbazide may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to thiosemicarbazide.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
4. Transport to a health care facility.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to thiosemicarbazide.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Remove contaminated clothing and shoes as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas thoroughly with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
7. Transport to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. DO NOT induce vomiting.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 30 to 100 g (1 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 30 to 100 g (1 to 3-1/2 oz) is recommended for adults.
6. Transport to health care facility. (EPA, 1998)

• 1-AMINO-2-THIOUREA
• AMINOTHIOUREA
• 1-AMINOTHIOUREA
• HYDRAZINECARBOTHIOAMIDE
• ISOTHIOSEMICARBAZIDE
• N-AMINO THIOUREA
• N-AMINOTHIOUREA
• SEMICARBAZIDE, THIO-
• SEMICARBAZIDE,THIO-
• SEMICARBIZIDE,3-THIO
• THIASEMICARBAZIDE
• THIOCARBAMOYLHYDRAZINE
• THIOCARBAMYLHYDRAZINE
• THIOSEMICARBAZIDE
• 2-THIOSEMICARBAZIDE
• TSC
• TSZ
• USAF EK-1275