STRYCHNINE SULFATE

Colorless, odorless, very bitter crystals or white crystalline powder. Has been used as a tonic and stimulant in veterinary medicine. Registered as a rodenticide in the U.S. (EPA, 1998)

none

No rapid reaction with air. No rapid reaction with water.

When heated to decomposition, it emits very toxic fumes of sulfur oxides and nitrogen oxides. Avoid alkalies, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric acids, salicylates, borax, gold chloride and other alkaloid precipitants, piperazine, potassium-mercuric iodide. Protect from light. (EPA, 1998)

Violent poison!. Lowest published lethal dose orally in humans is 30 mg/kg. (EPA, 1998)

STRYCHNINE SULFATE is a salt of strychnine. Strychnine is an alkaloid derivative which forms water soluble salts with acids.

Strychnine salts are incompatible with alkalis, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric acids, salicylates, borax, gold chloride and other alkaloid precipitants, piperazine, potassium-mercuric iodide. Protect from light. [EPA, 1998].

Strychnine is incompatible with the following: Strong oxidizers (NIOSH, 2022).

• Amides and Imides
• Ethers
• Hydrocarbons, Aromatic
• Salts, Acidic

No information available.

Excerpt from 151 [Substances - Toxic (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

(Non-Specific -- Strychnine and Salts) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing.

(Non-Specific -- Strychnine and Salts) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Move container from fire area if you can do it without risk. (EPA, 1998)

(Non-Specific -- Strychnine and Salts) Do not touch spilled material; stop leak if you can do it without risk.

Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal.

Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area.

Large spills: dike far ahead of spill for later disposal. (EPA, 1998)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

No information available.

Warning: Strychnine sulfate may induce convulsions within 15 to 60 minutes following exposure. Caution is advised. Vital signs should be monitored closely.

Signs and Symptoms of Acute Strychnine Sulfate Exposure: Signs and symptoms of acute exposure to strychnine sulfate generally involve excitation of all portions of the central nervous system. Convulsions, bilateral horizontal nystagmus (rapid, synchronous, horizontal oscillations of the eyeballs), agitation, restlessness, apprehension, and abrupt, jerking movements of the extremities may occur. Victims may also experience stiffness, painful muscle cramping (especially in the legs), opisthotonos (spasm in which the spine and extremities are bent with convexity forward, the body resting on the head and heels), and vomiting. Respiratory paralysis and arrest are likely to occur following severe exposure to strychnine sulfate. Cyanosis (blue tint to skin and mucous membranes), rhabdomyolysis (destruction of skeletal muscle), and renal failure may also be found.

Emergency Life-Support Procedures: Acute exposure to strychnine sulfate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to strychnine sulfate.Warning: Any unnecessary sensory input may induce seizures. Isolate the victims from any avoidable distractions.
2. RUSH to a health care facility!
3. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self- exposure to strychnine sulfate.Warning: Any unnecessary sensory input may induce seizures. Isolate the victims from any avoidable distractions.
2. RUSH to a health care facility!
3. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
4. Remove contaminated clothing as soon as possible.
5. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
6. THOROUGHLY wash exposed skin areas with soap and water.
7. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.Warning: Any unnecessary sensory input may induce seizures. Isolate the victims from any avoidable distractions.
2. RUSH to a health care facility!
3. DO NOT induce vomiting or attempt to neutralize.
4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. (EPA, 1998)

• ANTIVAMPIRE
• 4,6-METHANO-6H,14H-INDOLO[3,2,1-IJ]OXEPINO[2,3,4-DE]PYRROLO[2,3-H]QUINOLINE, STRYCHNIDIN-10-ONE DERIV.
• STRYCHNIDIN-10-ONE, SULFATE(2:1)
• STRYCHNINE SULFATE
• STRYCHNINE, SULFATE
• STRYCHNINE, SULFATE (2:1)
• STRYCHNINE, SULFATE(2:1)
• STRYCHNINE, [SULFATE]
• STRYCHNINIUM SULFATE
• VAMPIROL