PHOSPHONOTHIOIC ACID, METHYL-, S-(2-(BIS(1-METHYLETHYL)AMINO)ETHYL) O-ETHYL ESTER

Odorless liquid, with an amber color. Used as a quick-acting military chemical nerve agent.

none

No rapid reaction with air. No rapid reaction with water.

Highly toxic nitrogen oxides and sulfur oxides. Avoid extreme heat. (EPA, 1998)

Cholinesterase inhibitor. Lowest toxic oral dose (TDLO) to humans is 4 mg/kg; lowest lethal skin dose to humans (LDLO) is 86 mg/kg. Death within 15 minutes after fatal dose is absorbed. (EPA, 1998)

Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

• Amines, Phosphines, and Pyridines
• Sulfonates, Phosphonates, and Thiophosphonates, Organic

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below.

• Mineral-Based & Clay-Based Absorbents

Excerpt from 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: If this material is being used as a weapon, see ERG Table 1 - Initial Isolation and Protective Action Distances on the 153 datasheet for unassigned UN/NA numbers . Otherwise increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

Use protective clothing and respiratory protection. (EPA, 1998)

Decontaminants include bleach slurry and hot soapy water. (EPA, 1998)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Normalized Breakthrough Times (in Minutes)

Chemical	CAS Number	State	QS	QC	SL	C3	TF	TP	RC	TK	RF
VX Nerve Agent, FINABEL 0.7.C	50782-69-9	Liquid					>1400⁸	>1400⁸
VX Nerve Agent, MIL-STD-282 (10 g/m2)	50782-69-9	Liquid			>480⁸	>480⁸			>480⁸	>480⁸	>480⁸
VX Nerve Agent, MIL-STD-282 (100 g/m2)	50782-69-9	Liquid					>480⁸	>480⁸	>480⁸	>480⁸	>480⁸

Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be used around heat, flames, sparks or in potentially flammable or explosive environments. Only...

(DuPont, 2023)

Warning: Immediate decontamination of the smallest drop is essential. Death can occur 15 minutes after a fatal dose is absorbed.

Note: Phosphonothioic acid, methyl-, S-(2-(bis(l-methylethyl) amino)ethyl) O-ethyl ester is an extremely active cholinesterase inhibitor.

Signs and Symptoms of Phosphonothioic acid, methyl-, S-(2-(bis(l methylethyl)amino)ethyl) O-ethyl ester exposure: The first indication of exposure to phosphonothioic acid, methyl-, S-(2-(bis(l-methylethyl) amino) ethyl) O-ethyl ester may be a reaction at the point of contact: localized sweating, muscle twitching, and pinpoint eye pupils. Rhinorrhea (running nose), tightness of the chest with shortness of breath, and dimness of vision may be noted. In more severe exposure, headache, cramps, nausea, vomiting, involuntary defecation and urination, twitching, jerking, staggering, convulsions, drowsiness, coma, and respiratory arrest may be seen.

Emergency Life-Support Procedures: Acute exposure to phosphonothioic acid, methyl-, S-(2-(bis(l methylethyl)amino)ethyl) O-ethyl ester may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to phosphonothioic acid, methyl-, S-(2-(bis(l- methylethyl)amino)ethyl) O-ethyl ester.
2. RUSH to a health care facility!
3. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. DO NOT perform mouth-to-mouth resuscitation when facial contamination exists. If breathing is labored, administer oxygen or other respiratory support.
4.Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to phosphonothioic acid, methyl-, S-(2- (bis(l-methylethyl)amino)ethyl) O-ethyl ester.
2. RUSH to a health care facility!
3. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. DO NOT perform mouth-to-mouth resuscitation when facial contamination exists. If breathing is labored, administer oxygen or other respiratory support.
4. Remove and isolate contaminated clothing as soon as possible.
5. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
6. Wash exposed skin areas thoroughly with commercial household bleach and then flush with water. Avoid contacting the eyes or mouth with bleach.
7. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. DO NOT perform mouth-to-mouth resuscitation when facial contamination exists. If breathing is labored, administer oxygen or other respiratory support.
2. RUSH to a health care facility!
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. DO NOT induce vomiting or attempt to neutralize!
5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. (EPA, 1998)

• A 4
• ETHYL S-DIMETHYLAMINO- ETHYL METHYLPHOSPHONOTHIOLATE
• ETHYL-S-DIISOPROPYLAMINOETHYL METHYLTHIOPHOSPHONATE
• MPT
• O-ETHYL S-(2-DIISOPROPYLAMINOETHYL) METHYLPHOSPHONOTHIOATE
• O-ETHYL S-(2-DIISOPROPYLAMINOETHYL) METHYLTHIOPHOSPHONATE
• O-ETHYL S-DIISOPROPYLAMINOETHYL METHYLPHOSPHONOTHIOATE
• PHOSPHONOTHIOIC ACID, METHYL-, S-(2-(BIS(1-METHYLETHYL
• PHOSPHONOTHIOIC ACID, METHYL-, S-(2-(BIS(1-METHYLETHYL)AMINO)ETHYL) O-ETHYL ESTER
• PHOSPHONOTHIOIC ACID, METHYL-, S-(2-(DIISOPROPYLAMINO)ETHYL) O-ETHYL ESTER
• S-(2-DIISOPROPYLAMINOETHYL) O-ETHYL METHYLPHOSPHONOTHIOLATE
• S-2-DIISOPROPYLAMINOETHYL O-ETHYL METHYLPHOSPHONOTHIOATE
• S-[2-(DIISOPROPYLAMINO)ETHYL] O-ETHYL METHYLPHOSPHONOTHIOLATE
• TX 60
• VX (CHEMICAL WARFARE AGENT)
• VX AGENT
• VX VAPOR