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Chemical Datasheet
Chemical Identifiers
CAS Number |
UN/NA Number |
DOT Hazard Label |
USCG CHRIS Code |
- 51-75-2
|
none
|
data unavailable
|
none
|
NIOSH Pocket Guide |
International Chem Safety Card |
none
|
none
|
NFPA 704
data unavailable
General Description
Mobile liquid; faint odor of herring. Used as a drug for the treatment of cancer. Formerly used as a gas warfare agent.
Hazards
Reactivity Alerts
none
Air & Water Reactions
No rapid reaction with air. No rapid reaction with water.
Fire Hazard
Undiluted liquid decomposes on standing. (EPA, 1998)
Health Hazard
Toxic doses as low as 400 mg/kg have been reported in humans. Blood clots may occur at site of intravenous injection and tissue damage if outside vein. Powerful vesicant (causes blisters) when it contacts skin, mucous membranes, or eyes. Delayed toxicity -- missed menstrual periods, alopecia (hair loss), hearing loss, tinnitus (ringing in ears), jaundice, impaired spermatogenesis and germinal aplasia, swelling, and hypersensitivity. May damage fetus in pregnant women. (EPA, 1998)
Reactivity Profile
MECHLORETHAMINE is a chlorinated amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Belongs to the Following Reactive Group(s)
- Amines, Phosphines, and Pyridines
- Halogenated Organic Compounds
Potentially Incompatible Absorbents
Use caution: Liquids with this reactive group classification have been
known to react with the
absorbent
listed below.
- Mineral-Based & Clay-Based Absorbents
Response Recommendations
Isolation and Evacuation
Excerpt from 153
[Substances - Toxic and/or Corrosive (Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: If this material is being used as a weapon, see ERG Table 1 - Initial Isolation and Protective Action Distances on the 153 datasheet for unassigned UN/NA numbers
. Otherwise increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)
Firefighting
(Non-Specific -- Poisonous Liquid, n.o.s.) Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Move container from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.
(Non-Specific -- Poisonous Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. (EPA, 1998)
Non-Fire Response
(Non-Specific -- Poisonous Liquid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors.
Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal.
Large spills: dike far ahead of spill for later disposal. (EPA, 1998)
Protective Clothing
For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
Warning: Mechlorethamine is a strong irritant. Direct contact may result in severe dermal or corneal burns. Effects may be delayed.
Signs and Symptoms of Mechlorethamine Exposure: Signs and symptoms of acute exposure to mechlorethamine may include strong irritation or burning of the eyes, skin, and respiratory tract. Blisters, local phlebitis (irritation of a vein) and erythema (redness of the skin) may be noted. It may cause nausea, vomiting, and severe esophageal or gastrointestinal tract irritation if ingested. Bronchopneumonia, suppression of bone marrow activity, and hearing loss are possible longer term symptoms.
Emergency Life-Support Procedures: Acute exposure to mechlorethamine may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to mechlorethamine.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
4. Rush to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to mechlorethamine.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Remove and isolate contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. Speed in removing material from the eyes is of extreme importance.
5. Wash exposed skin areas thoroughly with soap and water. Speed in removing material from skin is of extreme importance.
6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
7. Rush to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support to all victims.
2. DO NOT induce vomiting or attempt to neutralize!
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.
5. Rush to a health care facility. (EPA, 1998)
Physical Properties
Flash Point: data unavailable
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point:
-76°F
(EPA, 1998)
Vapor Pressure: data unavailable
Vapor Density (Relative to Air): data unavailable
Specific Gravity:
1.118
at 77°F
(EPA, 1998)
- Denser than water; will sink
Boiling Point:
189°F
at 18 mmHg
(EPA, 1998)
Molecular Weight:
156.07
(EPA, 1998)
Water Solubility: data unavailable
Ionization Energy/Potential: data unavailable
IDLH: data unavailable
AEGLs (Acute Exposure Guideline Levels)
Interim AEGLs for Nitrogen Mustard-2 (51-75-2)
Exposure Period |
AEGL-1 |
AEGL-2 |
AEGL-3 |
10 minutes |
NR |
0.13 mg/m3 |
2.2 mg/m3 |
30 minutes |
NR |
0.044 mg/m3 |
0.74 mg/m3 |
60 minutes |
NR |
0.022 mg/m3 |
0.37 mg/m3 |
4 hours |
NR |
0.0056 mg/m3 |
0.093 mg/m3 |
8 hours |
NR |
0.0028 mg/m3 |
0.047 mg/m3 |
(NAC/NRC, 2023)
ERPGs (Emergency Response Planning Guidelines)
No ERPG information available.
PACs (Protective Action Criteria)
Chemical |
PAC-1 |
PAC-2 |
PAC-3 |
Nitrogen mustard-2; (Bis(b-chloroethyl)methylamine) (51-75-2)
|
0.002 mg/m3 |
0.022 mg/m3 |
0.37 mg/m3 |
(DOE, 2018)
Regulatory Information
EPA Consolidated List of Lists
Regulatory Name |
CAS Number/ 313 Category Code |
EPCRA 302 EHS TPQ |
EPCRA 304 EHS RQ |
CERCLA RQ |
EPCRA 313 TRI |
RCRA Code |
CAA 112(r) RMP TQ |
2-Chloro-N-(2-chloroethyl)-N-methylethanamine |
51-75-2 |
10 pounds |
10 pounds |
|
X |
|
|
Mechlorethamine |
51-75-2 |
10 pounds |
10 pounds |
|
X |
|
|
Nitrogen mustard |
51-75-2 |
10 pounds |
10 pounds |
|
313 |
|
|
(EPA List of Lists, 2022)
CISA Chemical Facility Anti-Terrorism Standards (CFATS)
|
RELEASE |
THEFT |
SABOTAGE |
Chemical of Interest |
CAS Number |
Min Conc |
STQ |
Security Issue |
Min Conc |
STQ |
Security Issue |
Min Conc |
STQ |
Security Issue |
HN2 (nitrogen mustard-2); [Bis(2-chloroethyl)methylamine] |
51-75-2 |
|
|
|
|
CUM 100 grams |
CW/CWP |
|
|
|
(CISA, 2007)
OSHA Process Safety Management (PSM) Standard List
No regulatory information available.
Alternate Chemical Names
- BETA,BETA'-DICHLORODIETHYL-N-METHYLAMINE
- BIS(2-CHLORO- ETHYL)METHYLAMINE
- BIS(2-CHLOROETHYL)METHYLAMINE
- BIS(BETA-CHLOROETHYL)METHYLAMINE
- CARYOLYSIN
- CHLORAMINE(THE NITROGEN MUSTARD)
- CHLORETHAZINE
- CHLORMETHINE
- 2-CHLORO-N-(2-CHLOROETHYL)- N-METHYLETHANAMINE
- 2-CHLORO-N-(2-CHLOROETHYL)-N-METHYLETHANAMINE
- CLORAMIN
- DI(2-CHLOROETHYL) METHYLAMINE
- DI(2-CHLOROETHYL)METHYLAMINE
- DICHLOR AMINE
- 2,2'-DICHLORO-N-METHYLDIETHYLAMINE
- DIETHYLAMINE, 2,2'-DICHLORO-N-METHYL-
- EMBICHIN
- ENT-25294
- ETHANAMINE, 2-CHLORO-N-(2-CHLOROETHYL)-N-METHYL-
- HN-2 (CHEMICAL WARFARE AGENT)
- HN2 (AMINE)
- HN2 (CHEMICAL WARFARE AGENT)
- MBA
- MECHLORETHAMINE
- METHYL-BETA,BETA-DICHLORODIETHYLAMINE
- METHYLBIS(2-CHLOROETHYL)AMINE
- METHYLBIS(BETA-CHLOROETHYL)AMINE
- METHYLBIS(CHLOROETHYLAMINE)
- METHYLDI(2-CHLOROETHYL)AMINE
- MUSTARGEN
- MUSTINE
- N,N-BIS(2-CHLOROETHYL)METHYLAMINE
- N,N-DI(CHLOROETHYL)METHYLAMINE
- N-METHYL-2,2'-DICHLORODIETHYLAMINE
- N-METHYL-BIS(2-CHLOROETHYL)AMINE
- N-METHYL-BIS(BETA-CHLOROETHYL)AMINE
- N-METHYLBIS(2-CHLOROETHYL)AMINE
- N-METHYLBIS(BETA-CHLOROETHYL)AMINE
- NITROGEN MUSTARD
- NSC 762
- TL 146