FLUOROURACIL

White to nearly white crystalline powder; practically odorless. Used as an anti neoplastic drug, chemosterilant for insects. (EPA, 1998)

none

Insoluble in water.

Emits very toxic fumes of flourides and nitrogen oxides when heated to decomposition. Avoid decomposing heat. (EPA, 1998)

Minimum toxic dose in humans is approximately 450 mg/kg (total dose) over 30 days for the ingested drug. Intravenous minimum toxic dose in humans is a total dose of 6 mg/kg over three days. Depression of white blood cells occurred after intravenous administrative of a total dose of 480 mg/kg over 32 days. Occasional neuropathy and cardiac toxicity have been reported. Do not use during pregnancy. Patients with impaired hepatic or renal function, with a history of high-dose pelvic irradiation or previous use of alkylating agents should be treated with extreme caution. Patients with nutritional deficiencies and protein depletion have a reduced tolerance to fluorouracil. (EPA, 1998)

FLUOROURACIL may be sensitive to prolonged exposure to light. Solutions discolor on storage. This chemical can react with oxidizing agents and strong bases. Incompatible with methotrexate sodium. (NTP, 1992)

• Amides and Imides
• Hydrocarbons, Aliphatic Unsaturated
• Fluorinated Organic Compounds

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below.

• Dirt/Earth

No information available.

(Non-Specific -- Drugs or Medicines, n.o.s. (Solid) Poison B) Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. Wear boots, protective gloves, and goggles. Wear self-contained breathing apparatus.

(Non-Specific -- Drugs or Medicines, n.o.s. (Solid) Poison B) Extinguish fire using agent suitable for type of surrounding fire (material itself burns with difficulty). Use water in flooding quantities as fog. Use "alcohol" foam, carbon dioxide or dry chemical. (EPA, 1998)

(Non-Specific -- Drugs) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. If water pollution occurs, notify appropriate authorities. Spill or leak: shut off ignition sources; no flares, smoking or flames in hazard area. Keep combustibles (wood, paper, oil etc.) away from spilled material. Do not touch spilled material.

Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal.

Large spills: dike far ahead of spill for later disposal. (EPA, 1998)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Normalized Breakthrough Times (in Minutes)

Chemical	CAS Number	State	QS	QC	SL	C3	TF	TP	RC	TK	RF
Fluorouracil, 5- (50 mg/ml)	51-21-8	Liquid		>240

Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be used around heat, flames, sparks or in potentially flammable or explosive environments. Only...

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Signs and Symptoms of Acute Fluorouracil Exposure: Nausea, vomiting, and diarrhea are the earliest symptoms of exposure to fluorouracil. Inflammation or sores in the mouth, gastric burning, and gastrointestinal bleeding may occur in more severe cases. Other symptoms include visual disturbances, lacrimation (tearing), chest pain and tachycardia (rapid heart rate).

Emergency Life-Support Procedures: Acute exposure to fluorouracil may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to fluorouracil.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Transport to a health care facility.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to fluorouracil.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas thoroughly with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Transport to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of fluorouracil is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4. Ipecac should not be administered to children under 6 months of age.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3- 1/2 oz) is recommended for adults.
6. Transport to a health care facility. (EPA, 1998)

• ADRUCIL
• ARUMEL
• CARZONAL
• 2,4-DIOXO-5-FLUOROPYRIMIDINE
• EFFLUDERM (FREE BASE)
• EFUDEX
• EFUDIX
• EFURIX
• FLUORO URACIL
• 5-FLUORO- 2,4-PYRIMIDINEDIONE
• 5-FLUORO-2,4(1H,3H)-PYRIMIDINEDIONE
• 5-FLUORO-2,4-PYRIMIDINEDIONE
• FLUOROBLASTIN
• FLUOROPLEX
• 5-FLUOROPYRIMIDINE- 2,4-DIONE
• 5-FLUOROPYRIMIDINE-2,4-DIONE
• FLUOROURACIL
• 5-FLUOROURACIL
• FLURACIL
• FLURACILUM
• FLURI
• FLURIL
• FT-207
• FTORURACIL
• FU
• 5-FU
• 2,4(1H,3H)-PYRIMIDINEDIONE, 5-FLUORO-
• NSC 19893
• NSC-19893
• QUEROPLEX
• RO 2-9757
• TIMAZIN
• U-8953
• ULUP
• URACIL, 5-FLUORO-