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Chemical Datasheet
ERGOTAMINE TARTRATE |
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Chemical Identifiers
CAS Number |
UN/NA Number |
DOT Hazard Label |
USCG CHRIS Code |
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none
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NIOSH Pocket Guide |
International Chem Safety Card |
none
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none
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NFPA 704
data unavailable
General Description
Powder or liquid forms available as drugs. Used in obstetrics and in the treatment of migraine headaches. (EPA, 1998)
Hazards
Reactivity Alerts
none
Air & Water Reactions
Insoluble in water.
Fire Hazard
When heated to decomposition, it emits toxic fumes of nitrogen oxides. Protect from light and heat (EPA, 1998)
Health Hazard
High oral toxicity and a convulsant in humans.People with liver damage are at a greater risk. (EPA, 1998)
Reactivity Profile
ERGOTAMINE TARTRATE is sensitive to prolonged exposure to heat and light. (NTP, 1992). When heated to decomposition, it emits toxic fumes of nitrogen oxides. Protect from light and heat [EPA, 1998].
Belongs to the Following Reactive Group(s)
- Amides and Imides
- Amines, Phosphines, and Pyridines
- Salts, Acidic
- Acetals, Ketals, Hemiacetals, and Hemiketals
Potentially Incompatible Absorbents
Use caution: Liquids with this reactive group classification have been
known to react with the
absorbent
listed below.
- Mineral-Based & Clay-Based Absorbents
Response Recommendations
Isolation and Evacuation
Excerpt from 154
[Substances - Toxic and/or Corrosive (Non-Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)
Firefighting
Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Non-Fire Response
(Non-Specific -- Alkaloid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Do not touch spilled material; stop leak if you can do so without risk. Use water vapor to reduce vapors. Absorb spills with sand or other noncombustible absorbent material.
Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. For large spills, dike far ahead of spill for later disposal. (EPA, 1998)
Protective Clothing
For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
Warning: Effects may be delayed. Caution is advised. Vital signs should be monitored closely.
Signs and Symptoms of Ergotamine Tartrate Exposure: Acute ergotamine tartrate exposure may result in the following signs and symptoms: headache, slurring speech, hypertension or hypotension (high or low blood pressure), slow pulse, chest pain, blood clots, abdominal cramps, nausea, vomiting, diarrhea, weakness in legs, muscle pains, numbness, and tingling in extremities. Seizures and coma may also occur.
Emergency Life-Support Procedures: Acute exposure to ergotamine tartrate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to ergotamine tartrate.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Rush to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to ergotamine tartrate.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove and isolate contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas thoroughly with water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of ergotamine tartrate is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of ergotamine tartrate may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Rush to a health care facility. (EPA, 1998)
Physical Properties
Flash Point: data unavailable
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point:
397°F
decomposes
(EPA, 1998)
Vapor Pressure: data unavailable
Vapor Density (Relative to Air): data unavailable
Specific Gravity: data unavailable
Boiling Point: data unavailable
Molecular Weight:
1313.56
(EPA, 1998)
Water Solubility:
less than 1 mg/mL
at 68°F
(NTP, 1992)
Ionization Energy/Potential: data unavailable
IDLH: data unavailable
AEGLs (Acute Exposure Guideline Levels)
No AEGL information available.
ERPGs (Emergency Response Planning Guidelines)
No ERPG information available.
PACs (Protective Action Criteria)
Chemical |
PAC-1 |
PAC-2 |
PAC-3 |
Ergotamine tartrate (379-79-3)
|
0.91 mg/m3 |
10 mg/m3 |
32 mg/m3 |
(DOE, 2018)
Regulatory Information
EPA Consolidated List of Lists
Regulatory Name |
CAS Number/ 313 Category Code |
EPCRA 302 EHS TPQ |
EPCRA 304 EHS RQ |
CERCLA RQ |
EPCRA 313 TRI |
RCRA Code |
CAA 112(r) RMP TQ |
Ergotamine tartrate |
379-79-3 |
500/10000 pounds |
500 pounds |
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(EPA List of Lists, 2022)
CISA Chemical Facility Anti-Terrorism Standards (CFATS)
No regulatory information available.
OSHA Process Safety Management (PSM) Standard List
No regulatory information available.
Alternate Chemical Names
- COMPONENT OF CAFERGOT
- ERGAM
- ERGATE
- ERGOMAR
- ERGOTAMAN-3',6',18-TRIONE, 12'-HYDROXY-2'-METHYL-5'-(PHENYLMETHYL)-, (5'ALPHA)-, [R-(R*,R*)]-2,3-DIHYDROXYBUTANEDIOATE (2:1) (SALT)
- ERGOTAMAN-3',6',18-TRIONE, 12'-HYDROXY-2'-METHYL-5'-(PHENYLMETHYL)-,(5'ALPHA)-,[R-(R*,R*)]- 2,3-DIHYDROXYBUTANEDIOATE(2:1)(SALT)
- ERGOTAMINE BITARTRATE
- ERGOTAMINE TARTRATE
- ERGOTAMINE, TARTRATE (2:1) (SALT)
- ERGOTAMINE, TARTRATE(2:1)(SALT)
- ETIN
- EXMIGRA
- FEMERGIN
- GOTAMINE
- GOTAMINE TARTRATE
- GYNERGEN
- 8H-OXAZOLO[3,2-A]PYRROLO[2,1-C]PYRAZINE, ERGOTAMAN-3',6',18-TRIONE DERIV.
- INDOLO[4,3-FG]QUINOLINE, ERGOTAMAN-3',6',18-TRIONE DERIV.
- LINGRAINE
- LINGRAN
- NEO-ERGOTIN
- RIGETAMIN
- SECAGYN
- SECUPAN
- TARTRATE