4,6-DINITRO-O-CRESOL

A yellow solid. Emits toxic oxides of nitrogen fumes when heated to decomposition. Toxic by skin absorption, inhalation or ingestion. Soluble in alcohol, acetone, ether and solutions of sodium or potassium hydroxides.

none

Slightly soluble in water.

Excerpt from 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2020)

Extremely toxic material; probable oral lethal dose is 5-50 mg/kg in humans or between 7 drops and 1 teaspoonful for a 70 kg (150 lb.) person. (EPA, 1998)

This compound is incompatible with the following: Strong oxidizers (NIOSH, 2022). Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases.

4,6-DINITRO-O-CRESOL is explosive and is usually moistened with up to 10 percent water to reduce the hazard. [EPA, 1998].

• Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic
• Phenols and Cresols

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below.

• Cellulose-Based Absorbents
• Expanded Polymeric Absorbents

Excerpt from 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

Keep unnecessary people away; isolate hazard area. Stay upwind and keep out of low areas. Wear self-contained breathing apparatus and full protective clothing. Move container from fire area if you can do so without risk.

Extinguish fire with water, foam, dry chemical, carbon dioxide. (EPA, 1998)

Excerpt from 153 [Substances - Toxic and/or Corrosive (Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2020)

Excerpt from NIOSH Pocket Guide for Dinitro-o-cresol:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin:
• WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.
• DAILY - The worker should wash daily at the end of each work shift, and prior to eating, drinking, smoking, etc.

Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: DAILY - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises. (NIOSH, 2023)

Normalized Breakthrough Times (in Minutes)

Chemical	CAS Number	State	QS	QC	SL	C3	TF	TP	RC	TK	RF
Dinitro-o-cresol, 4,6- (sat in Methanol)	534-52-1	Liquid							>480	>480	>480
Dinitrocresol (sat in Methanol)	534-52-1	Liquid							>480	>480	>480

Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be used around heat, flames, sparks or in potentially flammable or explosive environments. Only...

(DuPont, 2023)

Warning: Effects may be delayed for several hours. Toxicity of dinitrocresol is enhanced by high ambient temperature and physical activity. Caution is advised.

Signs and Symptoms of Acute Dinitrocresol Exposure: Early manifestations of acute dinitrocresol exposure include fever, sweating, headache, and confusion. Blood pressure, pulse, and respiratory rate are often elevated. Severe exposure may result in restlessness, seizures, and coma. Other signs and symptoms include dyspnea (shortness of breath), cyanosis (blue tint to skin and mucous membranes), pulmonary edema, nausea, vomiting, and abdominal pain. Liver injury with associated jaundice, kidney failure, and cardiac arrhythmias are commonly noted. Dermal exposure results in yellow staining of the skin and may produce burns. Dinitrocresol may irritate and burn the eyes and mucous membranes.

Emergency Life-Support Procedures: Acute exposure to dinitrocresol may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to dinitrocresol.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. RUSH to a health care facility.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self- exposure to dinitrocresol.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas twice with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. RUSH to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. DO NOT induce vomiting.
4. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.
5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
7. RUSH to a health care facility. (EPA, 1998)

• ANTINONIN
• ANTINONNIN
• ARBOROL
• CAPSINE
• CHEMSECT DNOC
• DEGRASSAN
• DEKRYSIL
• DETAL
• DILLEX
• DINITRO
• 3,5-DINITRO-2-HYDROXYTOLUENE
• 4,6-DINITRO-2-METHYLPHENOL
• 2,4-DINITRO-6-METHYLPHENOL
• 4,6-DINITRO-O-CRESOL AND SALTS
• 2,6-DINITRO-O-CRESOL
• 3,5-DINITRO-O-CRESOL
• 4,6-DINITRO-O-CRESOL
• DINITROCRESOL
• DINITRODENDTROXAL
• DINITROL
• DINITROMETHYL CYCLOHEXYLTRIENOL
• DINITROSOL
• DINOC
• DINURANIA
• DITROSOL
• DN-DRY MIX NO. 2
• DNC
• DNOC
• EFFUSAN
• EFFUSAN 3436
• ELGETOL
• ELGETOL 30
• ELIPOL
• ENT 154
• EXTRAR
• FLAVIN-SANDOZ
• HEDOLIT
• HEDOLITE
• K III
• K IV
• KRENITE
• KREOZAN
• KRESAMONE
• KREZOTOL 50
• LIPAN
• 6-METHYL-2,4-DINITROCRESOL
• 6-METHYL-2,4-DINITROPHENOL
• 2-METHYL-4,6-DINITROPHENOL
• NEUDORFF DN 50
• NITROFAN
• O-CRESOL, 4,6-DINITRO-
• PHENOL, 2-METHYL-4,6-DINITRO
• PROKARBOL
• RAFEX
• RAFEX 35
• RAPHATOX
• SANDOLIN
• SANDOLIN A
• SELINON
• SINOX
• TOLUENE, 3,5-DINITRO-2-HYDROXY-
• WINTERWASH