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Chemical Datasheet

NITROGEN TETROXIDE

2.3 - Poisonous gas 5.1 - Oxidizer 8 - Corrosive

Chemical Identifiers

CAS Number UN/NA Number DOT Hazard Label USCG CHRIS Code
  • 10544-72-6   (NITROGEN TETROXIDE)
  • 1067
  • Poison Gas
  • Oxidizer
  • Corrosive
  • NOX
NIOSH Pocket Guide International Chem Safety Card
none none
NFPA 704
Diamond Hazard Value Description
0
3 0
ox
Blue Health 3 Can cause serious or permanent injury.
Red Flammability 0 Will not burn under typical fire conditions.
Yellow Instability 0 Normally stable, even under fire conditions.
White Special OX Possesses oxidizing properties.
(NFPA, 2010)
General Description
Red-brown liquid with a sharp, unpleasant chemical odor. Low-boiling (boiling point 21.15°C) and held as a liquid by compression. Density 1.448 g / cm3. Consists of an equilibrium mixture of brown NO2 (nitrogen dioxide) and colorless N2O4 (dinitrogen tetroxide). Evolves poisonous brown vapors. Cylinders and ton containers may not be equipped with a safety relief device. Prolonged exposure of the containers to fire or heat may result in their violent rupturing and rocketing.

Hazards

Reactivity Alerts
Air & Water Reactions
Reacts with water to form nitric acid and nitric oxide.
Fire Hazard
Special Hazards of Combustion Products: Produces toxic gas when heated.

Behavior in Fire: Does not burn, but supports combustion of combustible materials such as wood. May cause fire or explode on contact with other materials. (USCG, 1999)
Health Hazard
Very concentrated fumes produce coughing, choking, headache, nausea, pain in chest and abdomen; otherwise, few symtoms appear at time of exposure. After symptom-free period of 5-72 hours, pulmonary edema gradually develops, causing fatigue, restlessness, coughing, difficulty in breathing, frothy expectoration, mental confusion, lethargy, bluish skin, and weak, rapid pulse. Since NOX interferes with gas exchange in lungs, unconscious- ness and death by asphyxiation can result, usually within a few hours after onset of pulmonary edema. (USCG, 1999)
Reactivity Profile
Liquid NITROGEN TETROXIDE is an oxidizing agent consisting of an equilibrium mixture of colorless dinitrogen tetraoxide (N2O4) and red-brown nitrogen dioxide (NO2). The exact composition of the mixture depends on the temperature with higher temperature favoring conversion to NO2. Vaporizes readily to give NO2, also an oxidizing agent. Noncombustible but can accelerate the burning of combustible materials. Reacts with reducing agents to generate heat and products that may be gaseous (causing pressurization of closed containers). The products may themselves be capable of further reactions (such as combustion in the air). Reacts with alkalis to form nitrates and nitrites [Merck 11th ed. 1989]. Corrodes steel if wet, but can be stored in steel cylinders if dry [Merck]. Reacts explosively with liquid ammonia even at very low temperatures (below its freezing point) [Mellor, 1940, Vol. 8, 54]. Reacts energetically with boron trichloride [Mellor, 1946, Vol. 5, 132]. Mixtures with metal carbonyls are hypergolic (enflame immediately). Mixtures with halocarbons, hydrazine derivatives, heterocyclic bases (pyridine), isopropyl nitrite/propyl nitrite, active metals (magnesium, calcium, etc.), nitroaromatics, nitrogen trichloride, phosphorus, triethylamine, unsaturated hydrocarbons may react explosively. Accidental mixing with hot cyclohexane caused an explosion [MCA Case History 128. 1962]. A mixture with acetonitrile and indium showed no evidence of change for a time and then detonated when shaken (ascribed to the catalyzed oxidation of acetonitrile) [Chem. & Ind., 1958, 1004]. Mixture with alcohols produced a violent explosion [Chem. Eng. News, 1955, 33, 2372]. Vapor reacts with barium oxide incandescently [Mellor, 1940, Vol. 8, 545]. A slow reaction between the vapor and formaldehyde became explosive near 180°C [Trans. Faraday Soc. 45:767-770. 1949]. Manganese and potassium both ignite in the vapor [Ann. Chem. et Phys.(2) 2:317]. The vapor and ozone react with the evolution of light and often explode when mixed [J. Chem. Phys. 18:366. 1920].
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below.

Response Recommendations

Isolation and Evacuation
Excerpt from ERG Guide 124 [Gases - Toxic and/or Corrosive - Oxidizing]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 1067 datasheet.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Firefighting
Fire Extinguishing Agents: Stop flow of gas (USCG, 1999)
Non-Fire Response
Excerpt from ERG Guide 124 [Gases - Toxic and/or Corrosive - Oxidizing]:

Do not touch or walk through spilled material. Keep combustibles (wood, paper, oil, etc.) away from spilled material. Stop leak if you can do it without risk. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Do not direct water at spill or source of leak. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Isolate area until gas has dispersed. Ventilate the area. (ERG, 2024)
Protective Clothing
Rubber gloves; safety goggles and face shield; protective clothing; acid gas canister respirator or self-contained breathing apparatus. (USCG, 1999)
DuPont Tychem® Suit Fabrics
Normalized Breakthrough Times (in Minutes)
Chemical CAS Number State QS QC SL C3 TF TP RC TK RF
Nitrogen tetroxide 10544-72-6 Liquid >480 >480 >480
Nitrogen tetroxide (21°C, liquid) 10544-72-6 Liquid 450
Nitrogen tetroxide (gaseous) 10544-72-6 Vapor 90 90 90
> indicates greater than.

Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be used around heat, flames, sparks or in potentially flammable or explosive environments. Only...

(DuPont, 2024)

First Aid
INHALATION: remove patient to fresh air and have him breathe as deeply as possible; call a doctor; enforce complete rest for 24-48 hours; keep warm; give oxygen if coughing starts; physician may administer morphine (10 mg.)

EYES AND

SKIN: flush with water for at least 15 min. (USCG, 1999)

Physical Properties

Chemical Formula:
  • N2O4
Flash Point: data unavailable
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: Not flammable (USCG, 1999)
Melting Point: 11.8°F (USCG, 1999)
Vapor Pressure: 1551 mmHg (USCG, 1999)
Vapor Density (Relative to Air): data unavailable
Specific Gravity: 1.45 at 68°F (USCG, 1999) - Denser than water; will sink
Boiling Point: 70.1°F at 760 mmHg (USCG, 1999)
Molecular Weight: 92.02 (USCG, 1999)
Water Solubility: data unavailable
Ionization Energy/Potential: data unavailable
IDLH: data unavailable

AEGLs (Acute Exposure Guideline Levels)

Final AEGLs for Nitrogen Tetroxide (10544-72-6)
Exposure Period AEGL-1 AEGL-2 AEGL-3
10 minutes 0.25 ppm 10 ppm 17 ppm
30 minutes 0.25 ppm 7.6 ppm 13 ppm
60 minutes 0.25 ppm 6.2 ppm 10 ppm
4 hours 0.25 ppm 4.1 ppm 7 ppm
8 hours 0.25 ppm 3.5 ppm 5.7 ppm
(NAC/NRC, 2024)

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
Nitrogen tetroxide (10544-72-6) 0.25 ppm 6.2 ppm 10 ppm
(DOE, 2024)

Regulatory Information

EPA Consolidated List of Lists

Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
Nitrogen dioxide 10544-72-6 10 pounds @

(EPA List of Lists, 2024)

CISA Chemical Facility Anti-Terrorism Standards (CFATS)

RELEASE THEFT SABOTAGE
Chemical of Interest CAS Number Min Conc STQ Security
Issue
Min Conc STQ Security
Issue
Min Conc STQ Security
Issue
Dinitrogen tetroxide 10544-72-6 3.80 % 15 pounds WME

(CISA, 2007)

OSHA Process Safety Management (PSM) Standard List

Chemical Name CAS Number Threshold Quantity (TQ)
Nitrogen Tetroxide (also called Nitrogen Peroxide) 10544-72-6 250 pounds

(OSHA, 2019)

Alternate Chemical Names