ISOPHORONE DIISOCYANATE

Diamond	Hazard	Value	Description
1 2 1 W	Health	2	Can cause temporary incapacitation or residual injury.
	Flammability	1	Must be preheated before ignition can occur.
	Instability	1	Normally stable but can become unstable at elevated temperatures and pressures.
	Special	W	Reacts violently or explosively with water.

A clear to light-yellow liquid. Slightly denser than water and insoluble in water. Toxic by inhalation and skin absorption. Very irritating to skin. Used to make polyurethane coatings.

• Water-Reactive

Insoluble in water. This chemical may be sensitive to moisture.

When heated to decomposition, it emits toxic fumes of nitrogen oxides. (EPA, 1998)

This material is highly toxic by inhalation and moderately toxic through the skin. (Non-Specific -- Isocyanates) People with skin or respiratory problems should avoid exposure. (EPA, 1998)

ISOPHORONE DIISOCYANATE reacts with all substances containing active hydrogen atoms such as water, alcohols, phenols, amines, mercaptans, amides, urethanes and ureas. (NTP, 1992)

• Isocyanates and Isothiocyanates

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below.

• Cellulose-Based Absorbents
• Mineral-Based & Clay-Based Absorbents
• Dirt/Earth

Excerpt from 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Remove and isolate contaminated clothing at the site.

Small fires: dry chemical, carbon dioxide, water spray or foam. Large fires: water spray, fog or foam. Move container from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material. (EPA, 1998)

Excerpt from 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. A vapor-suppressing foam may be used to reduce vapors. FOR CHLOROSILANES, use AFFF alcohol-resistant medium-expansion foam to reduce vapors. DO NOT GET WATER on spilled substance or inside containers. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas.

SMALL SPILL: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal. (ERG, 2020)

Excerpt from NIOSH Pocket Guide for Isophorone diisocyanate:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: DAILY - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.

Provide: QUICK DRENCH - Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2023)

No information available.

Signs and Symptoms of Isophorone Diisocyanate Exposure: Signs and symptoms of isophorone diisocyanate exposure include the following: itching skin, skin rashes, tearing of the eyes, inflammation of nasal mucous membrane, and respiratory irritation. Gastrointestinal irritation may also occur. Difficulty in breathing and skin rash may be observed upon re-exposure.

Emergency Life-Support Procedures: Acute exposure to isophorone diisocyanate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to isophorone diisocyanate.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% humidified oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with isophorone diisocyanate contaminated persons or their gastric contents may result in self poisoning.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Rush to a health care facility.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to isophorone diisocyanate.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% humidified oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with isophorone diisocyanate contaminated persons or their gastric contents may result in self poisoning.
3. Remove and isolate contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas thoroughly with water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Rush to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% humidified oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with isophorone diisocyanate contaminated persons or their gastric contents may result in self poisoning.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. DO NOT induce vomiting or attempt to neutralize!
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.
6. Rush to a health care facility. (EPA, 1998)

• CYCLOHEXANE, 5-ISOCYANATO- 1-(ISOCYANATOMETHYL)-1,3,3-TRIMETHYL-
• IPDI
• 5-ISOCYANATO-1-(ISOCYANATOMETHYL)-1,3,3-TRIMETHYL CYCLOHEXANE
• 5-ISOCYANATO-1-(ISOCYANATOMETHYL)-1,3,3-TRIMETHYLCYCLOHEXANE
• 1-ISOCYANATO-3,3,5-TRIMETHYL-5-(ISOCYANATOMETHYL)CYCLOHEXANE
• 1-ISOCYANATO-3-(ISOCYANATOMETHYL)-3,5,5-TRIMETHYLCYCLOHEXANE
• 1-ISOCYANATO-5-(ISOCYANATOMETHYL)-3,3,5-TRIMETHYLCYCLOHEXANE
• 3-(ISOCYANATOMETHYL)-3,5,5-TRIMETHYLCYCLOHEXYL ISOCYANATE
• 1-(ISOCYANATOMETHYL)-5-ISOCYANATO-1,3,3-TRIMETHYLCYCLOHEXANE
• 3-ISOCYANATOMETHYL-3,5,5- TRIMETHYLCYCLOHEXYLISOCYANATE
• 3-ISOCYANATOMETHYL-3,5,5-TRIMETHYLCYCLOHEXYL-ISOCYANATE
• 3-ISOCYANATOMETHYL-3,5,5-TRIMETHYLCYCLOHEXYLISOCYANATE
• ISOCYANIC ACID, METHYLENE(3,5,5-TRIMETHYL-3,1-CYCLOHEXYLENE) ESTER
• ISOPHORONE DIAMINE DIISOCYANATE
• ISOPHORONE DIISOCYANATE
• 1,3,3-TRIMETHYL-1-(ISOCYANATOMETHYL)-5-ISOCYANATOCYCLOHEXANE
• 3,3,5-TRIMETHYL-5-(ISOCYANATOMETHYL)CYCLOHEXYL ISOCYANATE