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Chemical Datasheet
CHLOROFORM |
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Chemical Identifiers
CAS Number |
UN/NA Number |
DOT Hazard Label |
USCG CHRIS Code |
- 67-66-3
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NIOSH Pocket Guide |
International Chem Safety Card |
Chloroform
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NFPA 704
General Description
A clear colorless liquid with a characteristic odor. Denser (12.3 lb / gal) than water and slightly soluble in water. Hence sinks in water. Nonflammable under most conditions, but burns under extreme conditions. May cause illness by inhalation, skin absorption or ingestion. Used as a solvent, to make other chemicals, as a fumigant.
Hazards
Reactivity Alerts
none
Air & Water Reactions
Slightly soluble in water. Dissolves in water to form a corrosive solution of hypochlorous acid which decomposes on standing to chlorine, oxygen, and chloric acid.
Fire Hazard
Container may explode in the heat of fire. When heated it liberates phosgene, hydrogen chloride, chlorine and toxic and corrosive oxides of carbon and chlorine. Chloroform explodes when in contact with aluminum powder or magnesium powder or with alkali metals (e.g., lithium, sodium, and potassium) and dinitrogen tetroxide. It reacts vigorously with acetone in the presence of potassium hydroxide or calcium hydroxide. It is oxidized by strong oxidizers such as chromic acid forming phosgene and chlorine. It reacts vigorously with triisopropylphosphine. It develops acidity from prolonged exposure to air and light. (EPA, 1998)
Health Hazard
It is classified as moderately toxic. Probable oral lethal dose for humans is 0.5 to 5 g/kg (between 1 ounce and 1 pint) for a 150 lb. person. The mean lethal dose is probably near 1 fluid ounce (44 g). It is a human suspected carcinogen. Also, it is a central nervous system depressant and a gastrointestinal irritant. It has caused rapid death attributable to cardiac arrest and delayed death from liver and kidney damage. (EPA, 1998)
Reactivity Profile
A mixture of acetone and CHLOROFORM in a residue bottle exploded. Since addition of acetone to chloroform in the presence of base will result in a highly exothermic reaction, it is thought that a base was in the bottle. [MCA Case History 1661(1970)]. Powdered aluminum and carbon tetrachloride (also methyl chloride and chloroform or mixtures of these chemicals) exploded when heated (to 153°C) and by impact, [Chem. Eng. News 32:258(1954); UL Bull. Research 34 (1945), ASESB Pot. Incid. 39(1968)]. An inadequately cooled addition of sodium to a chloroform-methanol mixture (sodium methoxide) caused a violent explosion, [MCA Case History No. 693]. It is incompatible with dinitrogen tetraoxide, fluorine, sodium metal and alcohols, nitromethane, and triisopropylphosphine.
Belongs to the Following Reactive Group(s)
- Halogenated Organic Compounds
Potentially Incompatible Absorbents
No information available.
Response Recommendations
Isolation and Evacuation
Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Firefighting
Wear self-contained breathing apparatus and special protective clothing. Move container from fire area. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.
Extinguish with dry chemical, carbon dioxide, water spray, fog or foam. (EPA, 1998)
Non-Fire Response
Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust. (ERG, 2024)
Protective Clothing
Excerpt from NIOSH Pocket Guide for Chloroform:
Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.
Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.
Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.
Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Change: No recommendation is made specifying the need for the worker to change clothing after the workshift.
Provide:
• EYEWASH - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection.
• QUICK DRENCH - Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2024)
DuPont Tychem® Suit Fabrics
Normalized Breakthrough Times (in Minutes)
Chemical |
CAS Number |
State |
QS |
QC |
SL |
C3 |
TF |
TP |
RC |
TK |
RF |
Chloro form |
67-66-3 |
Liquid |
|
imm |
imm |
imm |
imm |
imm |
>480 |
>480 |
>480 |
Chloro form (1000 ppm) |
67-66-3 |
Vapor |
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|
>480 |
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Trichloro methane |
67-66-3 |
Liquid |
|
imm |
imm |
imm |
imm |
imm |
>480 |
>480 |
>480 |
Trichloro methane (1000 ppm) |
67-66-3 |
Vapor |
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|
|
|
>480 |
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Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be
used around heat, flames, sparks or in potentially flammable or
explosive environments. Only...
(DuPont, 2024)
First Aid
Signs and Symptoms of Chloroform Exposure: Signs and symptoms of acute exposure to chloroform vapor may include conjunctivitis and blepharospasm (twitching of the eyelid). Burning pain and corneal epithelium injury may occur from chloroform liquid splashed in the eye. Acute exposure may also lead to respiratory depression, chemical pneumonitis, pulmonary edema, metabolic acidosis, central nervous system depression, headache, fatigue, and dizziness. Gastrointestinal signs and symptoms include nausea, vomiting, salivation, anorexia, and gastrointestinal irritation. Cardiac arrhythmias and cardiac arrest have been reported.
Emergency Life-Support Procedures: Acute exposure to chloroform may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to chloroform.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for performance of invasive procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to chloroform.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove and isolate contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 30 minutes.
5. Wash exposed skin areas thoroughly with water.
6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. DO NOT induce vomiting.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility. (EPA, 1998)
Physical Properties
Flash Point:
None
(EPA, 1998)
Lower Explosive Limit (LEL):
None
(EPA, 1998)
Upper Explosive Limit (UEL):
NoneNone
(EPA, 1998)
Autoignition Temperature:
Not flammable
(USCG, 1999)
Melting Point:
-82.3°F
(EPA, 1998)
Vapor Pressure:
100 mmHg
at 50.72°F
(EPA, 1998)
Vapor Density (Relative to Air):
4.12
(EPA, 1998)
- Heavier than air; will sink
Specific Gravity:
1.4832
at 68°F
(EPA, 1998)
- Denser than water; will sink
Boiling Point:
143°F
at 760 mmHg
(EPA, 1998)
Molecular Weight:
119.39
(EPA, 1998)
Water Solubility:
less than 1 mg/mL
at 66°F
(NTP, 1992)
Ionization Energy/Potential:
11.42 eV
(NIOSH, 2024)
IDLH:
500 ppm
; A potential occupational carcinogen.
(NIOSH, 2024)
AEGLs (Acute Exposure Guideline Levels)
Final AEGLs for Chloroform (67-66-3)
Exposure Period |
AEGL-1 |
AEGL-2 |
AEGL-3 |
10 minutes |
NR |
120 ppm |
4000 ppm |
30 minutes |
NR |
80 ppm |
4000 ppm |
60 minutes |
NR |
64 ppm |
3200 ppm |
4 hours |
NR |
40 ppm |
2000 ppm |
8 hours |
NR |
29 ppm |
1600 ppm |
(NAC/NRC, 2024)
ERPGs (Emergency Response Planning Guidelines)
Chemical |
ERPG-1 |
ERPG-2 |
ERPG-3 |
Chloroform (67-66-3)
|
NA |
50 ppm |
5000 ppm |
(AIHA, 2022)
PACs (Protective Action Criteria)
Chemical |
PAC-1 |
PAC-2 |
PAC-3 |
Chloroform (67-66-3)
|
2 ppm |
64 ppm |
3200 ppm |
(DOE, 2024)
Regulatory Information
EPA Consolidated List of Lists
Regulatory Name |
CAS Number/ 313 Category Code |
EPCRA 302 EHS TPQ |
EPCRA 304 EHS RQ |
CERCLA RQ |
EPCRA 313 TRI |
RCRA Code |
CAA 112(r) RMP TQ |
Chloroform |
67-66-3 |
10000 pounds |
10 pounds |
10 pounds |
313 |
U044 |
20000 pounds |
Methane, trichloro- |
67-66-3 |
10000 pounds |
10 pounds |
10 pounds |
X |
U044 |
20000 pounds |
(EPA List of Lists, 2024)
CISA Chemical Facility Anti-Terrorism Standards (CFATS)
|
RELEASE |
THEFT |
SABOTAGE |
Chemical of Interest |
CAS Number |
Min Conc |
STQ |
Security Issue |
Min Conc |
STQ |
Security Issue |
Min Conc |
STQ |
Security Issue |
Chloroform; [Methane, trichloro-] |
67-66-3 |
1.00 % |
20000 pounds |
toxic |
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(CISA, 2007)
OSHA Process Safety Management (PSM) Standard List
No regulatory information available.
Alternate Chemical Names
- CHLOROFORM
- FORMYL TRICHLORIDE
- FREON 20
- HCC 20
- METHANE TRICHLORIDE
- METHANE, TRICHLORO-
- METHENYL CHLORIDE
- METHENYL TRICHLORIDE
- METHYL TRICHLORIDE
- NCI-C02686
- NCI-CO2686
- R 20
- R 20 (REFRIGERANT)
- R 20(REFRIGERANT)
- R-20
- TCM
- TRICHLOROFORM
- TRICHLOROMETHANE