TOLBUTAMIDE

PHYSICAL DESCRIPTION: White crystals. (NTP, 1992)

none

Insoluble in water.

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)

SYMPTOMS: Symptoms of exposure to this chemical may include aplastic anemia, hypoglycemia, nausea, vomiting, weakness, intolerance to alcohol, skin eruptions, and rarely, leukopenia, thrombocytopenia, thyroid suppression, hyperlipemia or gastrointestinal bleeding from ulcers.

ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits very toxic fumes. (NTP, 1992)

TOLBUTAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). This chemical is incompatible with acids. (NTP, 1992).

• Amides and Imides
• Sulfonates, Phosphonates, and Thiophosphonates, Organic

No information available.

No information available.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

• AGLICID
• ARKOZAL
• ARTOSIN
• ARTOZIN
• BUTAMID
• BUTAMIDE
• 1-BUTYL-3-(P-METHYLPHENYLSULFONYL)UREA
• 1-BUTYL-3-(P-TOLYLSULFONYL)UREA
• 1-BUTYL-3-TOSYLUREA
• BZ 55
• D 860
• DIABEN
• DIABETAMID
• DIABETOL
• DIABUTON
• DOLIPOL
• DRABET
• HLS 831
• IPOGLICONE
• MOBENOL
• N-((BUTYLAMINO)CARBONYL)-4-METHYLBENZENESULFONAMIDE
• N-(4-METHYLBENZENESULFONYL)-N'-BUTYLUREA
• N-(4-METHYLPHENYLSULFONYL)-N'-BUTYLUREA
• N-(P-METHYLBENZENESULFONYL)-N'-BUTYLUREA
• N-(P-TOLYLSULFONYL)-N'-BUTYLCARBAMIDE
• N-(SULFONYL-P-METHYLBENZENE)-N'-N-BUTYLUREA
• N-BUTYL-N'-(4-METHYLPHENYLSULFONYL)UREA
• N-BUTYL-N'-(P-TOLYLSULFONYL)UREA
• N-BUTYL-N'-P-TOLUENESULFONYLUREA
• N-BUTYL-N'-TOLUENE-P-SULFONYLUREA
• N-N-BUTYL-N'-TOSYLUREA
• NCI-C01763
• ORABET
• ORALIN
• OREZAN
• ORINASE
• ORINAZ
• OTERBEN
• 1-P-TOLUENESULFONYL-3-BUTYLUREA
• 3-(P-TOLYL-4-SULFONYL)-1-BUTYLUREA
• RASTINON
• SK-TOLBUTAMIDE
• TOLBUSAL
• TOLBUTAMID
• TOLBUTAMIDE
• TOLUINA
• TOLUMID
• TOLUMIDE
• TOLURAN
• TOLUVAN
• TOLYLSULFONYLBUTYLUREA
• UREA, 1-BUTYL-3-(P-TOLYLSULFONYL)-
• WILLBUTAMIDE