THEOPHYLLINE

PHYSICAL DESCRIPTION: Odorless white crystalline powder. Odorless. Bitter taste. (NTP, 1992)

none

Slightly soluble in water.

Flash point data for this chemical are not available, however it is probably combustible. (NTP, 1992)

SYMPTOMS: Symptoms of exposure to this compound include nausea, vomiting, epigastric pain, hematemesis, diarrhea, headaches, irritability, restlessness, insomnia, reflex hyperexcitability, muscle twitching, clonic and tonic generalized convulsions, palpitations, tachycardia, extrasystoles, potentiation of diuresis, hyperglycemia, flushing, hypotension, tachypnea, albuminuria, inappropriate ADH secretion and rash. Other symptoms include collapse, a fall in blood pressure; coma, hyperreflexia, ventricular arrythmias including fibrillation, hypotension, respiratory arrest, restlessness, fever, agitation and hyperventilation. It may also cause central nervous system stimulation, nervousness, insomnia, tremors, hyperesthesia, stimulation of the medullary respiratory centers; apnea, emesis, decreases in peripheral vascular resistance; increased perfusion of most organs and death.

ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of NOx. (NTP, 1992)

THEOPHYLLINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

• Amides and Imides
• Amines, Phosphines, and Pyridines

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below.

• Mineral-Based & Clay-Based Absorbents

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Fires involving this compound can be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this material under ambient temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

• AMINOPHYLLINE
• ARMOPHYLLINE
• ASMAX
• AUSTYN
• 3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE
• 1,3-DIMETHYLXANTHINE
• DURAPHYL
• EGIFILIN
• ELAN
• ELIXOPHYLLIN
• ELIXOPHYLLINE
• EUPHYLONG
• 1H-PURINE-2,6-DIONE
• LANOPHYLLIN
• LIQUOPHYLLINE
• NSC 2066
• NUELIN
• OPTIPHYLLIN
• PARKOPHYLLIN
• PSEUDOTHEOPHYLLINE
• QUIBRON T/SR
• QUIBRON-T
• SLO-PHYLLIN
• SOLOSIN
• SPOPHYLLIN RETARD
• TEONOVA
• THEO-DUR
• THEOCIN
• THEODEL
• THEOFOL
• THEOGRAD
• THEOLAIR
• THEONA P
• THEOPHYLLIN
• THEOPHYLLINE
• THEOPHYLLINE, ANHYDROUS
• THEOTARD
• UNIPHYLLIN