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Chemical Datasheet

4,4'-SULFONYLDIANILINE

Chemical Identifiers

CAS Number UN/NA Number DOT Hazard Label USCG CHRIS Code
  • 80-08-0
 none data unavailable none
NIOSH Pocket Guide International Chem Safety Card
none none
NFPA 704
data unavailable
General Description
PHYSICAL DESCRIPTION: Odorless white or creamy white crystalline powder. Slightly bitter taste. (NTP, 1992)

Hazards

Reactivity Alerts
none
Air & Water Reactions
Sensitive to oxidation and light. Insoluble in water.
Fire Hazard
This chemical is probably combustible. (NTP, 1992)
Health Hazard
SYMPTOMS: Symptoms of exposure to this compound include somnolence, retinal changes, cyanosis, jaundice, changes in tubules and other kidney changes, hemolysis with or without anemia, joint effects, hepatitis, dermatitis and peripheral neuritis. Other symptoms include peripheral motor neuropathy, retinal damage, optic atrophy and, in large doses, intravascular hemolysis, methemoglobinemia, renal failure, hemorrhages and exudates in fundi, localized capillary non-perfusion by angiography, and permanent poor vision. Prolonged skin exposure may lead to irritation. Severe eye irritation, irritation of the nose and throat and sneezing also occur. Exposure may cause restlessness, coma, hematuria, gastrointestinal irritation, maculopapular, erythematous skin eruptions, fever, mental disturbances, visual disturbances, oliguria or anuria with azotemia, agranulocytosis, thrombocytopenia, purpura, conjunctival injection, bullous lesions of the skin, petechiae, increased erythema, injury from sunlight, renal damage and death. It may also cause sore throat, pallor, aplastic anemia, other blood dyscrasias, exfoliative dermatitis, erythema multiforme, toxic epidermal necrolysis, morbilliform and scarlatiniform reactions, urticaria, erythema nodosum, muscle weakness, nausea, vomiting, abdominal pain, vertigo, blurred vision, tinnitus, insomnia, headache, psychosis, phototoxicity, tachycardia, albuminuria, the nephrotic syndrome, hypoalbuminemia without proteinuria, renal papillary necrosis, male infertility, drug-induced lupus erythematosus, an infectious mononucleosis-like syndrome, severe anoxia, hyperexcitability, methemoglobin induced depression and convulsions. Other symptoms may include anorexia, dizziness, nervousness, lymphadenitis, fixed drug eruptions, and eosinophilia. This compound can cause Heinz-body formation, paresthesia, pruritus, exacerbation of lepromatous leprosy in malnourished persons, malaise, hepatic necrosis and lymphadenopathy. It can also cause leukopenia, pseudo-leukemia and abnormalities in liver function tests.

ACUTE/CHRONIC HAZARDS: This compound is harmful if swallowed, inhaled or absorbed through the skin. It may cause irritation. When heated to decomposition it emits very toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides and sulfur oxides. (NTP, 1992)
Reactivity Profile
4,4'-SULFONYLDIANILINE can neutralize acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. Incompatible with strong oxidizing agents. Also incompatible with epoxy resins under uncontrolled conditions (NTP, 1992).
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

No information available.

Response Recommendations

Isolation and Evacuation
No information available.
Firefighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
Non-Fire Response
SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)
Protective Clothing
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

Physical Properties

Chemical Formula:
  • C12H12N2O2S
Flash Point: greater than 320°F (NTP, 1992)
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point: 347 to 349°F (NTP, 1992)
Vapor Pressure: data unavailable
Vapor Density (Relative to Air): 8.3 (NTP, 1992) - Heavier than air; will sink
Specific Gravity: 1.33 at 77°F (NTP, 1992) - Denser than water; will sink
Boiling Point: data unavailable
Molecular Weight: 248.3 (NTP, 1992)
Water Solubility: less than 1 mg/mL at 68°F (NTP, 1992)
Ionization Energy/Potential: data unavailable
IDLH: data unavailable

AEGLs (Acute Exposure Guideline Levels)

No AEGL information available.

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
Diaminodiphenylsulfone; (Dapsone, 4,4'-Sulfonyldianiline) (80-08-0) 2 mg/m3 22 mg/m3 78 mg/m3
(DOE, 2018)

Regulatory Information

EPA Consolidated List of Lists

No regulatory information available.

CISA Chemical Facility Anti-Terrorism Standards (CFATS)

No regulatory information available.

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

Alternate Chemical Names