SALICYLAZOSULFAPYRIDINE

PHYSICAL DESCRIPTION: Odorless yellow or brownish-yellow to orange powder. Tasteless. (NTP, 1992)

It is a sulfa drug used as an antibiotic.

• Explosive

Light sensitive and may be sensitive to prolonged exposure to air. Dust can be explosive when suspended in air at specific concentrations. Insoluble in water.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

SYMPTOMS: Symptoms of exposure to this compound include hemolytic Heinz-body anemia, transient reticulocytosis, cyanosis, leukopenia, agranulocytosis, neurotoxicity and pancreatitis. Other symptoms include nausea, vomiting, fever, headache, blood dyscrasias and methemoglobinemia. It can cause liver damage, thrombocytopenia and aplastic anemia. Other symptoms may include arthralgia, bronchospasm, pulmonary eosinophilia, peripheral neuropathy, rashes, hemolysis, gray skin color, tachycardia, epidermal necrolysis, erythroid hypoplasia, hemolysis in people who are deficient in erythrocyte glucose-6-phosphate dehydrogenase, red cell contraction, swing in temperature, rhonchi, pulmonary basal crepitations, increased erythrocyte sedimentation rates, eosinophilia, abnormal lung function, death from severe subacute fibrosing alveolitis, yellow skin and blood serum unrelated to jaundice, burning and itching sensation of the feet and ankles, nocturnal hallucinations, numbness, paresthesia in lower limbs, high stepping gait, incoordination of both lower limbs, impairment of sensation in all modes from the waist down, reversible male sterility, decreased semen quality and adenocarcinomas of the small intestine. This compound also causes necrotic or inflammatory lesions in the liver, heart, kidneys and bone marrow, hematuria, gastrointestinal irritation, maculopapular erythematous skin eruptions, mental and visual disturbances, sensitivity reactions, urticaria, pain on urination, oliguria or anuria with azotemia, purpura, conjunctival injection, bullous lesions of the skin, petechiae, jaundice, increased erythema or injury from sunlight and irreversible neuromuscular and central nervous system changes. Other symptoms are hypersensitivity reactions involving the lungs. Exposure may cause Stevens-Johnson syndrome, Lyell`s syndrome, salicylism, pulmonary reaction with associated pulmonary infiltration, reversible oligospermia, macrocytosis, erythroid and megakaryocytic aplasia, megaloblastic anemia, bloody diarrhea, hepatotoxicity, tracheolaryngitis, dyspnea, folic acid reduction, lupus erythematosus, Raynaud`s syndrome, scaling skin eruption, lymphadenopathy, orange-yellow urine and neutropenia. Ataxia may also occur.

ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides and sulfur oxides. (NTP, 1992)

No information available.

• Acids, Carboxylic
• Amides and Imides
• Azo, Diazo, Azido, Hydrazine, and Azide Compounds

No information available.

No information available.

Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, dampen the solid spill material with 5% ammonium hydroxide, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% ammonium hydroxide to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

• ACCUCOL
• ASULFIDINE
• AZOPYRIN
• AZOPYRINE
• AZULFIDINE
• BENZOSULFA
• 5-((P-(2-PYRIDYLSULFAMOYL)PHENYL)AZO)SALICYLIC ACID
• 5-(P-(2-PYRIDYLSULFAMOYL)PHENYLAZO)SALICYLIC ACID
• 5-[P-(2-PYRIDYLSULFAMOYL)PHENYLAZO]SALICYLIC ACID
• 5-[P-(2-PYRIDYLSULFAMYL)PHENYLAZO]SALICYLIC ACID
• 4-(PYRIDYL-2-AMIDOSULFONYL)-3'-CARBOXY-4'-HYDROXYAZOBENZENE
• 5-(4-(2-PYRIDYLSULFAMOYL)PHENYLAZO-2-HYDROXYBENZOIC ACID
• REUPIRIN
• RORASUL
• S.A.S.-500
• SALAZOPYRIDIN
• SALAZOPYRIN
• SALAZOPYRINE
• SALAZOSULFAPYRIDIN
• SALAZOSULFAPYRIDINE
• SALICYLAZOSULFAPYRIDINE
• SALICYLIC ACID, 5-((P-(2-PYRIDYLSULFAMOYL)PHENYL)AZO)-
• SALICYLIC ACID, 5-[[P-(2-PYRIDYLSULFAMOYL)PHENYL]AZO]-
• SALISULF
• SASP
• SULCOLON
• SULFASALAZIN
• SULFASALAZINE
• SULPHASALAZINE
• W-T SASP ORAL