PHENYL GLYCIDYL ETHER

PHYSICAL DESCRIPTION: Colorless liquid. (NTP, 1992)

• Peroxidizable Compound

Ethers tend to form unstable peroxides when exposed to oxygen. Ethyl, isobutyl, ethyl tert-butyl, and ethyl tert-pentyl ether are particularly hazardous in this respect. Ether peroxides can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Slightly soluble in water.

This chemical is probably combustible. (NTP, 1992)

Excerpt from NIOSH Pocket Guide for Phenyl glycidyl ether:

Exposure Routes: Inhalation, skin absorption, ingestion, skin and/or eye contact

Symptoms: Irritation eyes, skin; upper respiratory system; skin sensitization; narcosis; possible hematopoietic, reproductive effects; [potential occupational carcinogen]

Target Organs: Eyes, skin, central nervous system, hematopoietic system, reproductive system

Cancer Site: [in animals: nasal cancer] (NIOSH, 2023)

PHENYL GLYCIDYL ETHER, an ether, can act as a base. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.

• Ethers
• Epoxides

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below.

• Mineral-Based & Clay-Based Absorbents
• Dirt/Earth

Excerpt from 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

Fires involving this compound can be controlled using a dry chemical, carbon dioxide or Halon extinquisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this material in a refrigerator. STORE AWAY FROM SOURCES OF IGNITION. (NTP, 1992)

Excerpt from NIOSH Pocket Guide for Phenyl glycidyl ether:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: No recommendation is made specifying the need for the worker to change clothing after the workshift.

Provide:
• EYEWASH - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection.
• QUICK DRENCH - Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2023)

Normalized Breakthrough Times (in Minutes)

Chemical	CAS Number	State	QS	QC	SL	C3	TF	TP	RC	TK	RF
Phenyl glycidyl ether	122-60-1	Liquid			>480				>480

Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be used around heat, flames, sparks or in potentially flammable or explosive environments. Only...

(DuPont, 2023)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

• BENZENE, (2,3-EPOXYPROPOXY)-
• 2,3-EPOXY-1-PHENOXYPROPANE
• 1,2-EPOXY-3-PHENOXY PROPANE
• (.+-.)-1,2-EPOXY-3-PHENOXYPROPANE
• 1,2-EPOXY-3-PHENOXYPROPANE
• 2,3-EPOXYPROPOXYBENZENE
• 2,3-EPOXYPROPYL PHENYL ETHER
• ETHER, 2,3-EPOXYPROPYL PHENYL
• ETHER, PHENYLGLYCIDYL
• GAMMA-PHENOXYPROPYLENE OXIDE
• GLYCIDOL PHENYL ETHER
• GLYCIDYL PHENYL ETHER
• (.+-.)-GLYCIDYL PHENYL ETHER
• OXIRANE, (PHENOXYMETHYL)-
• OXIRANYLMETHYL PHENYL ETHER
• PGE
• PHENOL GLYCIDYL ETHER
• 3-PHENOXY-1,2-EPOXYPROPANE
• 3-PHENOXY-1,2-PROPYLENE OXIDE
• 3-PHENOXY-1-PROPENE OXIDE
• 1-PHENOXY-2,3-EPOXYPROPANE
• (PHENOXYMETHYL)OXIRANE
• (.+-.)-(PHENOXYMETHYL)OXIRANE
• 2-(PHENOXYMETHYL)OXIRANE
• PHENOXYPROPENE OXIDE
• 3-PHENOXYPROPYLENE OXIDE
• PHENYL 2,3-EPOXYPROPYL ETHER
• PHENYL GLYCIDYL ETHER
• (.+-.)-PHENYL GLYCIDYL ETHER
• 3-(PHENYLOXY)-1,2-EPOXYPROPANE
• PROPANE, 1,2-EPOXY-3-PHENOXY-