OXAZEPAM

PHYSICAL DESCRIPTION: Odorless creamy-white to pale-yellow powder or white crystalline solid. Bitter taste. pH (2% aqueous suspension) 4.8-7. (NTP, 1992)

none

Insoluble in water.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

SYMPTOMS: Symptoms of exposure to this compound include sedation, nausea, drowsiness, ataxia and coma (from large doses). Other symptoms include vomiting, lethargy, hyporeflexia, muscular weakness, dysarthria, nystagmus, hypotension, respiratory failure and death from respiratory or cardiac arrest. Exposure can cause syncope, liver damage, bone marrow damage and sensitivity reactions. It can also cause dryness of the mouth, aggressive behavior, blood dyscrasias and hepatic dysfunction. Sleepiness has been reported. It may cause lightheadedness, respiratory depression, constipation, changes in salivation, blurred vision, diplopia, urinary retention, incontinence, mental depression, tremor, headache, confusion, slurred speech, vertigo, changes in libido, blood disorders, jaundice, central nervous system depression and, sometimes, paradoxical reactions such as dysphoria. It may also cause skin rashes (morbilliform, urticarial and maculopapular), dizziness, stimulation of affect, leukopenia, severe rage reactions (rare), menstrual irregularities, change in EEG pattern, agranulocytosis, stupor, disorientation, fever, euphoria, transient amnesia and memory impairment. Exposure to children has resulted in somnolence, changes in REM sleep and loss of muscle control (ataxia). It has also caused lethargy, paradoxical excitation, depressed reflexes, facial edema, delirium, hallucinations and convulsions.

ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits very toxic fumes of nitrogen oxides and hydrogen chloride. (NTP, 1992)

OXAZEPAM is stable in light and is non hygroscopic. It is stable in neutral solution. This chemical is hydrolyzed by acids and bases. (NTP, 1992)

• Alcohols and Polyols
• Amides and Imides
• Aryl Halides
• Amines, Aromatic

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below.

• Cellulose-Based Absorbents

No information available.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this chemical under ambient temperatures and away from acids. This compound is a Schedule IV DEA Controlled Substance and is to be stored according to State and Federal Regulations. Refer to Code of Federal Regulations Title 21 Part 1300 to End. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

• ADUMBRAN
• ANSIOLISINA
• ANSIOXACEPAM
• ANXIOLIT
• ANXIOLIT RETARD
• APLAKIL
• ASTRESS
• BONARE
• 7-CHLORO-1,3-DIHYDRO-3-HYDROXY-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE
• 7-CHLORO-1,3-DIHYDRO-3-HYDROXY-5-PHENYL-2H-1,4-BENZODIAZEPINE-2-ONE
• 7-CHLORO-3-HYDROXY-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE
• DRIMUEL
• DROXACEPAM
• ENIDREL
• HI-LONG
• HILONG
• ISODIN
• LIMBIAL
• N-DESMETHYLTEMAZEPAM
• NESONTIL
• NOCTAZEPAM
• NORTEMAZEPAM
• NOTARAL
• NOZEPAM
• OX
• OXAZEPAM
• (.+-.)-OXAZEPAM
• PACIENX
• PRAXITEN
• PROPAX
• PSICOPAX
• PSIQUIWAS
• QUEN
• QUILIBREX
• RO 5-6789
• RONDAR
• (RS)-OXAZEPAM
• SERAX
• SERENAL
• SERENID
• SERENID-D
• SEREPAX
• SERESTA
• SERPAX
• SIGACALM
• SOBRIL
• TARCHOMIN
• TAZEPAM
• TRANQUO-BUSCOPAN-WIRKSTOFF
• VABEN
• WY 3498
• WY-3498
• Z10-TR