NIFEDIPINE

PHYSICAL DESCRIPTION: Odorless yellow crystals or powder. Tasteless. (NTP, 1992)

none

Aqueous solutions are very sensitive to light. (NTP, 1992). Insoluble in water.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

SYMPTOMS: Symptoms of exposure to this compound via ingestion include diabetes mellitus, hallucinations, distorted perceptions, cardiac effects, nausea, vomiting, changes in regional blood flow, dermatitis, anaphylaxis and decreased blood pressure. Other symptoms via ingestion include headache, dizziness, flushing, hypotension, tachycardia, fatigue and edema. It also causes dilation of coronary arteries and arterioles, reduced oxygen requirements, decreased platelet aggregation, weakness, heartburn, muscle cramps, tremor, nervousness, mood changes, palpitation, dyspnea, wheezing, cough, nasal congestion, sore throat, chest congestion, diarrhea, constipation flatulence, muscle inflammation, joint stiffness, shakiness, blurred vision, difficulties in balance, jitteriness, sleep disturbances, pruritus, urticaria, fever, sweating, chills, sexual difficulties and syncopal episodes. It can cause bradycardia, lethargy and anginal pain. It can also cause improved contractility and segmental ventricular function, increased heart rate and cardiac output, and increased peripheral blood flow due to arterial dilation (with no change in venous tone). It can cause negative inotropy, excessive vasodilation, depression of the sinus nodal rate, A-V nodal conduction disturbances, digital dysesthesia, sedation and aggravation of myocardial ischemia. Somnolence may occur.

ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides. (NTP, 1992)

NIFEDIPINE is sensitive to light.

• Amines, Phosphines, and Pyridines
• Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
• Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below.

• Cellulose-Based Absorbents
• Mineral-Based & Clay-Based Absorbents
• Expanded Polymeric Absorbents

No information available.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it under ambient temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

• ADALAT
• BAY 1040
• BAY A 1040
• BAY-A 1040
• CITILAT
• CORDAFEN
• CORDAFLEX
• CORDIPIN
• CORINFAR
• CORYNPHAR
• 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID DIMETHYL ESTER
• DIMETHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2'-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE
• DIMETHYL 4-(O-NITROPHENYL)-2,6-DIMETHYL-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE
• 2,6-DIMETHYL-3,5-DICARBOMETHOXY-4-(2-NITROPHENYL)-1,4-DIHYDROPYRIDINE
• 2,6-DIMETHYL-4-(2-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID DIMETHYL ESTER
• FENIHIDINE
• GLOPIR
• NIFEDIN
• NIFEDIPINE
• NIFEDIPINUM
• NIFELAT
• NIPHEDIPINE
• 4-(2'-NITROPHENYL)-2,6-DIMETHYL-3,5-DICARBOMETHOXY-1,4-DIHYDROPYRIDINE
• OXCORD
• PROCARDIA
• 3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-, DIMETHYL ESTER
• 3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(O-NITROPHENYL)-, DIMETHYL ESTER
• TN 873R