INDOMETHACIN

PHYSICAL DESCRIPTION: Crystals. (NTP, 1992)

none

Practically insoluble in water. Decomposes in alkali.

Excerpt from 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, 147 (lithium ion batteries) or 138 (sodium batteries) should also be consulted. (ERG, 2020)

SYMPTOMS: May cause gastrointestinal discomfort and possibly ulcerations. May aggravate psychiatric disturbances, epilepsy, and parkinsonism. May cause drowsiness and headache.

ACUTE/CHRONIC HAZARDS: Very toxic. Hazardous decomposition products. May aggravate central nervous system disorders. Suspected teratogen. (NTP, 1992)

A weak organic acid.

• Acids, Carboxylic
• Amides and Imides
• Hydrocarbons, Aromatic
• Aryl Halides

No information available.

Excerpt from 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

This compound is not very flammable but any fire involving this compound may produce dangerous vapors. You should evacuate the area. All firefighters should wear full-body protective clothing and use self-contained breathing apparatuses. You should extinguish any fires involving this chemical with a dry chemical, carbon dioxide, foam, or halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, you should dampen the solid spill material with alcohol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with alcohol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).

RECOMMENDED GLOVE MATERIALS: Permeation data indicate that nitrile gloves may provide protection to contact with this compound. Nitrile over latex gloves is recommended. However, if this chemical makes contact with your gloves, or if a tear, hole or puncture develops, remove them at once. (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

• ALPHA-(1-(P-CHLOROBENZOYL)-2-METHYL-5-METHOXY-3-INDOLYL)ACETIC ACID
• AMUNO
• ARTRINOVO
• ARTRIVIA
• BONIDON GEL
• 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID
• 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
• CHRONO-INDOCID 75
• CONFORTID
• DOLCIDIUM PL
• DOLOVIN
• IDOMETHINE
• INACID
• INDACIN
• INDMETHACINE
• INDO-RECTOLMIN
• INDOCID
• INDOCIN
• INDOLE-3-ACETIC ACID, 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-
• INDOMECOL
• INDOMED
• INDOMEE
• INDOMETACIN
• INDOMETACINE
• INDOMETHACIN
• INDOMETHACINE
• INDREN
• INFROCIN
• INTEBAN
• INTEBAN SP
• METACEN
• METARTRIL
• METHAZINE
• METINDOL
• MEZOLIN
• N-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
• 1-(P-CHLOROBENZOYL)-2-METHYL-5-METHOXY-3-INDOLEACETIC ACID
• 1-(P-CHLOROBENZOYL)-2-METHYL-5-METHOXYINDOLE-3-ACETIC ACID
• 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-3-INDOLYLACETIC ACID
• 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
• REUMACIDE
• SADOREUM
• USAN