4-HYDROXYPYRAZOLO(3,4-D)PYRIMIDINE

PHYSICAL DESCRIPTION: Odorless tasteless white microcrystalline powder. (NTP, 1992)

none

Insoluble in water.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

SYMPTOMS: Symptoms of exposure to this compound may include toxic epidermal necrolysis with pseudomembranous conjunctivitis and ulceration of the lids and conjunctivae of both corneas. Cataracts may also occur. It may also cause Lesch-Nyhan syndrome, lymphosarcoma, reduced serum and urinary uric acid levels, hepatotoxicity, drowsiness, xanthine crystalluria, death (rare), myeloma, congestive myocardial disease, painful urination, blood in the urine, swelling of the lips and mouth, alkaline phosphatase increase, SGOT/SGPT increase, acute attacks of gout, ecchymosis, necrotizing angiitis, hepatic necrosis, hyperbilirubinemia, gastritis, dyspepsia, thrombocytopenia, myopathy, peripheral neuropathy, neuritis, paresthesia, somnolence, epistaxis, Lyell's syndrome, purpura, dermatitis and salivary gland swelling. Other symptoms may include skin rashes, fever, nausea, vomiting, diarrhea, leukopenia and eosinophilia. Reversible liver impairment may also occur. Exposure may cause maculopapular rashes, pruritus, abdominal pain, malaise and headaches. Exposure may also cause erythematous skin eruptions, aching muscles, bone marrow depression, vertigo and gastric irritation. It may also cause exfoliative lesions, urticaria, purpuric skin rash, hepatomegaly and peripheral neuritis. Other symptoms of exposure to this chemical may include chills, leukocytosis, Stevens-Johnson syndrome, vasiculitis, anorexia, severe weight loss, acute renal failure, aplastic anemia and agranulocytosis. Exposure may also lead to hypersensitivity, arthralgia, alopecia, liver damage, oxypurine calculi, xanthine stones, ichthyosis, general weakness, severe allergic reactions, hepatic abnormalities, neutropenia, oliguria, uremia, extensive intracutaneous infections, sepsis, pneumonia, hepatic necrosis, cholangitis, pericholangitis, jaundice, lymphadenopathy, granulomas in the liver, nephritis, severe arteritis and sarcoidoisis. Muscle weakness may occur.

ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides. (NTP, 1992)

4-HYDROXYPYRAZOLO(3,4-D)PYRIMIDINE is an amine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. This chemical darkens above 572°F, and at an indefinite high temperature, it chars and decomposes. At 221°F, maximum stability occurs at pH 3.1- 3.4. This chemical decomposes in acidic and basic solutions.

• Amides and Imides
• Amines, Phosphines, and Pyridines

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below.

• Mineral-Based & Clay-Based Absorbents

Excerpt from 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, dampen the solid spill material with 5% ammonium hydroxide, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% ammonium hydroxide to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

• ADENOCK
• AL-100
• ALLOPUR
• ALLOPURINOL
• ALLOPURINOL(I)
• ALLOZYM
• ALLURAL
• ALOSITOL
• ALULINE
• ANOPROLIN
• ANZIEF
• APURIN
• APUROL
• ATISURIL
• BLEMINOL
• BLOXANTH
• BW 56-158
• CAPLENAL
• CELLIDRIN
• DABROSIN
• 1,5-DIHYDRO-4H-PYRAZOLO(3,4-D)PYRIMIDIN-4-ONE
• EMBARIN
• EPIDROPAL
• FOLIGAN
• GICHTEX
• GOTAX
• 1H-PYRAZOLO(3,4-D)PYRIMDIN-4-OL
• 4H-PYRAZOLO(3,4-D)PYRIMIDIN-4-ONE
• 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL
• HPP
• 4-HYDROXY-1H-PYRAZOLO(3,4-D)PYRIMIDINE
• 4-HYDROXY-1H-PYRAZOLO[3,4-D]PYRIMIDINE
• 4-HYDROXY-3,4-PYRAZOLOPYRIMIDINE
• 4-HYDROXYPYRAZOLO(3,4-D)PYRIMIDINE
• 4'-HYDROXYPYRAZOLOL(3,4-D)PYRIMIDINE
• 4-HYDROXYPYRAZOLOPYRIMIDINE
• 4-HYDROXYPYRAZOLO[3,4-D]PYRIMIDINE
• 4-HYDROXYPYRAZOLYL(3,4-D)PYRIMIDINE
• KETANRIFT
• KETOBUN-A
• LOPURIN
• LYSURON
• MILURIT
• MINIPLANOR
• MONARCH
• NEKTROHAN
• NSC-1390
• REMID
• RIBALL
• SUSPENDOL
• TAKANARUMIN
• URBOL
• URICEMIL
• URIPRIM
• URITAS
• UROBENYL
• UROSIN
• XANTURAT
• ZYLOPRIM
• ZYLORIC