GLYCIDOL

PHYSICAL DESCRIPTION: Odorless clear colorless liquid. (NTP, 1992)

• Polymerizable
• Water-Reactive

Sensitive to moisture.

This chemical is combustible. (NTP, 1992)

Excerpt from NIOSH Pocket Guide for Glycidol:

Exposure Routes: Inhalation, ingestion, skin and/or eye contact

Symptoms: Irritation eyes, skin, nose, throat; narcosis

Target Organs: Eyes, skin, respiratory system, central nervous system (NIOSH, 2023)

GLYCIDOL is sensitive to moisture. It is also sensitive to light. It may polymerize if heated above room temperature. It may darken on storage. Stability studies of this chemical stored for two week protected from light indicated definite decomposition at 140°F, and strongly indicated instability at 77°F. A solution of this compound in water was found to be unstable when stored at room temperature, even after one day in the dark. This chemical is incompatible with strong oxidizers. It will undergo explosive decomposition in the presence of strong acids or bases, salts (such as aluminum chloride, iron(III)chloride or tin(IV) chloride) or metals (such as copper and zinc). It is also incompatible with nitrates. It will attack some forms of plastics, rubber and coatings. (NTP, 1992)

• Alcohols and Polyols
• Epoxides
• Polymerizable Compounds

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below.

• Cellulose-Based Absorbents
• Mineral-Based & Clay-Based Absorbents
• Dirt/Earth

Excerpt from 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

Excerpt from NIOSH Pocket Guide for Glycidol:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: No recommendation is made specifying the need for the worker to change clothing after the workshift. (NIOSH, 2023)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

• ALLYL ALCOHOL OXIDE
• DL-GLYCIDOL
• EPIHYDRIN ALCOHOL
• EPIOL OH
• (.+-.)-2,3-EPOXY-1-PROPANOL
• 2,3-EPOXY-1-PROPANOL
• 1,2-EPOXY-3-HYDROXYPROPANE
• 2,3-EPOXYPROPANOL
• EPOXYPROPYL ALCOHOL
• GLYCIDE
• GLYCIDOL
• (.+-.)-GLYCIDOL
• GLYCIDYL ALCOHOL
• 3-HYDROXY-1,2-EPOXYPROPANE
• 1-HYDROXY-2,3-EPOXYPROPANE
• HYDROXYMETHYL ETHYLENE OXIDE
• 2-HYDROXYMETHYL OXIRAN
• 2-(HYDROXYMETHYL)OXIRANE
• 3-HYDROXYPROPYLENE OXIDE
• METHANOL, OXIRANYL-
• NCI-C55549
• OXIRANEMETHANOL
• OXIRANYLMETHANOL
• 1-PROPANOL, 2,3-EPOXY-
• RACEMIC GLYCIDOL
• (RS)-GLYCIDOL