FUROSEMIDE

PHYSICAL DESCRIPTION: Odorless white to slightly yellow crystalline powder. A diuretic drug. Almost tasteless. (NTP, 1992)

none

Light sensitive. Air sensitive. Slightly soluble in water.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

SYMPTOMS: Gastrointestinal system reactions to this compound may include anorexia, oral and gastric irritation, nausea, vomiting, cramping, diarrhea, constipation, jaundice and pancreatitis. Central nervous system reactions may include dizziness, vertigo, paresthesia, headache, xanthopsia, blurred vision, tinnitus and hearing loss. Hematologic reactions may include anemia, leukopenia, agranulocytosis, thrombocytopenia and aplastic anemia. Dermatologic-hypersensitivity reactions may include purpura, photosensitivity, rash, urticaria, necrotizing angiitis, exfoliative dermatitis, erythema multiforme and pruritus. Cardiovascular reactions may include orthostatic hypotension. Other symptoms may include hyperglycemia, glycosuria, hyperuricemia, muscle spasm, weakness, restlessness, urinary bladder spasm and thrombophlebitis. Fluid and electrolyte imbalance, allergies and liver damage may also occur. It may also cause tetany and dehydration. Other symptoms may include increased thirst, lethargy, drowsiness, fatigue, oliguria, tachycardia, reduction of plasma volume, circulatory collapse, thrombosis, embolism, convulsions, ataxia, paralysis and collapse.

ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits very toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides and hydrogen chloride gas. (NTP, 1992)

FUROSEMIDE may undergo hydrolysis at sufficiently low pH. The pH of aqueous solutions should be maintained in the basic range to prevent hydrolysis. Alcohol has been shown to improve the stability of this compound. Incompatible with strong oxidizing agents (NTP, 1992).

• Acids, Carboxylic
• Amides and Imides
• Amines, Phosphines, and Pyridines
• Ethers
• Aryl Halides

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below.

• Mineral-Based & Clay-Based Absorbents

No information available.

Fires involving this material can be controlled with a carbon dioxide, dry chemical or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

• AISEMIDE
• ALUZINE
• 5-(AMINOSULFONYL)-4-CHLORO-2-((2-FURANYLMETHY)AMINO)BENZOIC ACID
• ANTHRANILIC ACID, 4-CHLORO-N-FURFURYL-5-SULFAMOYL-
• BERONALD
• 4-CHLORO-N-(2-FURYLMETHYL)-5-SULFAMOYLANTHRANILIC ACID
• 4-CHLORO-N-FURFURYL-5-SULFAMOYLANTHRANILIC ACID
• DESDEMIN
• DIURAL
• DRYPTAL
• ERROLON
• EUTENSIN
• FRUSEMIDE
• FRUSEMIN
• FRUSID
• FULSIX
• FULUVAMIDE
• FURANTHRIL
• FURANTHRYL
• FURANTRIL
• FURESIS
• 2-FURFURYLAMINO-4-CHLORO-5-SULFAMOYLBENZOIC ACID
• FUROSEDON
• FUROSEMID
• FUROSEMIDE
• FUROSEMIDE "MITA"
• FURSEMID
• FURSEMIDE
• FUSID
• HYDRO-RAPID
• KATLEX
• LASEX
• LASILIX
• LASIX
• LB 502
• LOWPSTRON
• MACASIROOL
• NCI-C55936
• NICOROL
• PREFEMIN
• PROFEMIN
• RADONNA
• ROSEMIDE
• SALIX
• SEGURIL
• TRANSIT
• TROFURIT
• UREX
• UROSEMIDE