DACARBAZINE

PHYSICAL DESCRIPTION: White to ivory microcrystals or off-white crystalline solid. (NTP, 1992)

none

Insoluble in water.

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)

SYMPTOMS: Symptoms of exposure to this compound may include nausea, vomiting, bone marrow suppression, leukopenia, thrombocytopenia, hepatotoxicity, hepatic vein thrombosis and hepatocellular necrosis. Other symptoms may include hemopoietic depression, anemia, anaphylaxis, anorexia, diarrhea, facial paresthesias, death, and rarely, erythematous and urticarial rashes, and photosensitivity reactions. It may cause cardiovascular collapse, burning of the throat, abdominal pain, oliguria, anuria, delirium, fall of blood pressure, convulsions, muscular weakness with respiratory failure and collapse. Large doses may cause gastrointestinal bleeding. Exposure may also result in alopecia, facial flushing, and a flu-like syndrome of fever, myalgias and malaise. It can cause chills, dermatological reactions and neurotoxicity.

ACUTE/CHRONIC HAZARDS: There is limited evidence that this compound is carcinogenic in humans. When heated to its melting point it decomposes violently and emits toxic fumes of nitrogen oxides. (NTP, 1992)

DACARBAZINE decomposes explosively at its melting point (250°C). Decomposes in the presence of light. Sensitive to oxidation.

• Amides and Imides
• Amines, Phosphines, and Pyridines
• Azo, Diazo, Azido, Hydrazine, and Azide Compounds
• Hydrocarbons, Aliphatic Unsaturated

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below.

• Mineral-Based & Clay-Based Absorbents
• Dirt/Earth

No information available.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water fog may also be used. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

• BIOCARBAZINE R
• DACARBAZINE
• DETICENE
• DIC
• 5-(3,3-DIMETHYL-1-TRIAZENO)IMIDAZOLE-4-CARBOXAMIDE
• 4-(5)-(3,3-DIMETHYL-1-TRIAZENO)IMIDAZOLE-5(4)-CARBOXAMIDE
• 4-(3,3-DIMETHYL-1-TRIAZENO)IMIDAZOLE-5-CARBOXAMIDE
• 5-(3,3-DIMETHYL-1-TRIAZENYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
• 5-(DIMETHYLTRIAZENO)IMIDAZOLE-4-CARBOXAMIDE
• 5-(3,3-DIMETHYLTRIAZENO)IMIDAZOLE-4-CARBOXAMIDE
• 4-(DIMETHYLTRIAZENO)IMIDAZOLE-5-CARBOXAMIDE
• (DIMETHYLTRIAZENO)IMIDAZOLECARBOXAMIDE
• DTIC
• DTIC-DOME
• IMIDAZOLE-4(OR 5)-CARBOXAMIDE, 5(OR 4)-(3,3-DIMETHYL-1-TRIAZENO)-
• IMIDAZOLE-4-CARBOXAMIDE, 5-(3,3-DIMETHYL-1-TRIAZENO)-
• NCI-C04717
• NSC 45388
• NSC-45388