TRIS(AZIRIDINYL)PHOSPHINE SULFIDE

PHYSICAL DESCRIPTION: Odorless white crystalline solid. (NTP, 1992)

• Polymerizable

Water soluble.

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)

SYMPTOMS: Symptoms of exposure to this compound include nausea, anorexia, headache and vomiting. It may also cause leukopenia and thrombocytopenia. Other symptoms include bone-marrow depression, anemia, dizziness, amenorrhea, interference with spermatogenesis, alopecia and apnea. Febrile reaction and weeping from a subcutaneous lesion may occur as the result of breakdown of tumor tissue. Allergic reactions are rare, but hives and skin rash have been noted occasionally. Death from septicemia and hemorrhage has occurred as a direct result of hematopoietic depression. Other symptoms include granulocytopenia, hypoplasia of all elements of bone marrow, lymphopenia and precipitation of uric acid in kidney tubules. Exposure to this compound may also result in the development of acute nonlymphocytic leukemia.

ACUTE/CHRONIC HAZARDS: There is limited evidence that this compound is carcinogenic in humans. When heated to decomposition it emits highly toxic fumes of phosphorous oxides and sulfur oxides. It may also emit fumes of nitrogen oxides. (NTP, 1992)

TRIS(AZIRIDINYL)PHOSPHINE SULFIDE polymerizes readily upon exposure to heat or moisture, especially at acidic pH.

• Sulfides, Organic
• Peroxides, Organic
• Polymerizable Compounds

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below.

• Cellulose-Based Absorbents
• Mineral-Based & Clay-Based Absorbents
• Expanded Polymeric Absorbents
• Dirt/Earth

Excerpt from 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and protect it from moisture. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

Normalized Breakthrough Times (in Minutes)

Chemical	CAS Number	State	QS	QC	SL	C3	TF	TP	RC	TK	RF
Thiotepa (10 mg/ml)	52-24-4	Liquid		>240

Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be used around heat, flames, sparks or in potentially flammable or explosive environments. Only...

(DuPont, 2023)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

• AI 3-24916
• CBC 806495
• GIROSTAN
• N,N',N''-TRI-1,2-ETHANEDIYLPHOSPHOROTHIOIC TRIAMIDE
• N,N',N''-TRIETHYLENETHIOPHOSPHORAMIDE
• N,N',N''-TRIETHYLENETHIOPHOSPHORTRIAMIDE
• NCI-C01649
• NSC 6396
• NSC-6396
• ONCOTEPA
• ONCOTHIO-TEPA
• ONCOTIOTEPA
• PHOSPHINE SULFIDE, TRIS(1-AZIRIDINYL)-
• 1,1',1''-PHOSPHINOTHIOYLIDYNETRISAZIRIDINE
• PHOSPHOROTHIOIC ACID TRIETHYLENETRIAMIDE
• PHOSPHOROTHIOIC TRIAMIDE, N,N',N''-TRI-1,2-ETHANEDIYL-
• PHOSPHOROTHIOIC TRIAMIDE, N,N',N''-TRIETHYLENE-
• SK 6882
• STEPA
• TESPA
• TESPAMIN
• TESPAMINE
• THIO-TEP
• THIO-TEPA S
• THIOFOZIL
• THIOPHOSPHAMIDE
• THIOPHOSPHORAMIDE, N,N',N''-TRI-1,2-ETHANEDIYL-
• THIOPHOSPHORAMIDE, N,N',N''-TRIETHYLENE-
• THIOPLEX
• THIOTEF
• THIOTEPA
• THIOTRIETHYLENEPHOSPHORAMIDE
• TIFOSYL
• TIO-TEF
• TIOFOSFAMID
• TIOFOSYL
• TIOFOZIL
• TRI(ETHYLENEIMINO)THIOPHOSPHORAMIDE
• TRI-1-AZIRIDINYLPHOSPHINE SULFIDE
• TRIAZIRIDINYLPHOSPHINE SULFIDE
• TRIETHYLENETHIOPHOSPHORAMIDE
• TRIETHYLENETHIOPHOSPHOROTRIAMIDE
• TRIS(1-AZIRIDINYL)PHOSPHINE SULFIDE
• TRIS(AZIRIDINYL)PHOSPHINE SULFIDE
• TSPA