||DOT Hazard Label
||USCG CHRIS Code
|NIOSH Pocket Guide
||International Chem Safety Card
PHYSICAL DESCRIPTION: Clear colorless or slightly yellow liquid with the odor of sassafras. Denser than water (density 1.09 g / cm3) and insoluble in water. Hence sinks in water. Obtained from oil of sassafras or oil of camphor.
Air & Water Reactions
Insoluble in water.
This chemical is combustible. (NTP, 1992)
SYMPTOMS: This compound can cause vomiting, shock, cyanosis, delirium and probably convulsions.
ACUTE/CHRONIC HAZARDS: This material will cause severe irritation if ingested. (NTP, 1992)
SAFROLE, an acetal, is readily hydrolyzed in acidic solution to give 4-allylpyrocatechol and formaldehyde (or formaldehyde polymers).
Belongs to the Following Reactive Group(s)
- Hydrocarbons, Aliphatic Unsaturated
- Acetals, Ketals, Hemiacetals, and Hemiketals
Potentially Incompatible Absorbents
Use caution: Liquids with this reactive group classification have been
known to react with the
Isolation and Evacuation
Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)
Fires involving this compound should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should store this material in a refrigerator. STORE AWAY FROM SOURCES OF IGNITION. (NTP, 1992)
MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)
DuPont Tychem® Suit Fabrics
No information available.
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Vapor Density (Relative to Air): data unavailable
450 to 453°F
at 760 mmHg
less than 1 mg/mL
Ionization Energy/Potential: data unavailable
IDLH: data unavailable
AEGLs (Acute Exposure Guideline Levels)
No AEGL information available.
ERPGs (Emergency Response Planning Guidelines)
No ERPG information available.
PACs (Protective Action Criteria)
|Safrol; (5-(2-Propenyl)-1,3-benzodioxole) (94-59-7)
EPA Consolidated List of Lists
313 Category Code
(EPA List of Lists, 2022)
CISA Chemical Facility Anti-Terrorism Standards (CFATS)
No regulatory information available.
OSHA Process Safety Management (PSM) Standard List
No regulatory information available.
Alternate Chemical Names
- ALLYLCATECHOL METHYLENE ETHER
- ALLYLDIOXYBENZENE METHYLENE ETHER
- 4-ALLYLPYROCATECHOL FORMALDEHYDE ACETAL
- ALLYLPYROCATECHOL METHYLENE ETHER
- BENZENE, 4-ALLYL-1,2-(METHYLENEDIOXY)-
- 1,3-BENZODIOXOLE, 5-ALLYL-
- M-ALLYLPYROCATECHIN METHYLENE ETHER
- RHYUNO OIL
- SAFROLE MF