2-ACETYLAMINOFLUORENE

PHYSICAL DESCRIPTION: White powder or light beige solid. (NTP, 1992)

none

Insoluble in water.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Excerpt from NIOSH Pocket Guide for 2-Acetylaminofluorene:

Exposure Routes: Inhalation, skin absorption, ingestion, skin and/or eye contact

Symptoms: Reduced function of liver, kidneys, bladder, pancreas; [potential occupational carcinogen]

Target Organs: Liver, bladder, kidneys, pancreas, skin

Cancer Site: [in animals: tumors of the liver, bladder, lungs, skin & pancreas] (NIOSH, 2023)

2-ACETYLAMINOFLUORENE is incompatible with acids, bases and oxidizing agents. Ozone and chlorinating agents oxidize this compound (NTP, 1992).

• Amides and Imides
• Amines, Aromatic

No information available.

Excerpt from 171 [Substances (Low to Moderate Hazard)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: In cleanup of leaks or spills outside the laboratory hood, maintenance or repair operations on contaminated systems or equipment, where direct contact with this compound could result, each person entering that area should be provided with and required to wear, clean impervious garments, including gloves, boots and continuous air supplied hood-style respirator. To perform cleanup FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this chemical at ambient temperatures, and keep it away from oxidizing materials. (NTP, 1992)

Excerpt from NIOSH Pocket Guide for 2-Acetylaminofluorene:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin:
• WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.
• DAILY - The worker should wash daily at the end of each work shift, and prior to eating, drinking, smoking, etc.

Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: DAILY - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.

Provide:
• EYEWASH - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection.
• QUICK DRENCH - Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2023)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

• AAF
• 2-AAF
• ACETAMIDE, N-9H-FLUOREN-2-YL-
• ACETAMIDE, N-FLUOREN-2-YL-
• 2-ACETAMIDOFLUORENE
• 2-ACETAMINOFLUORENE
• ACETOAMINOFLUORENE
• 2-(ACETYLAMINO)FLUORENE
• 2-ACETYLAMINOFLUORENE
• FAA
• 2-FAA
• 2-FLUORENYLACETAMIDE
• N-2-FLUORENYLACETAMIDE
• N-9H-FLUOREN-2-YLACETAMIDE
• N-ACETYL-2-AMINOFLUORENE
• N-FLUOREN-2-YLACETAMIDE