AMINOPTERIN

Clusters of yellow needles. Used as a rodenticide, medicine and rodenticide. Not registered as a rodenticide in the U.S. (EPA, 1998)

none

No rapid reaction with air. No rapid reaction with water.

No information available.

An antimetabolite; antagonizes the utilization of folic acid by the body. Highly toxic by ingestion. (EPA, 1998)

[[Details on specifics of reactivity not yet available.]]

• Amines
• Amides and Imides, Organic
• Carboxylic Acids

No information available.

(Non-Specific -- Pesticide, Solid, n.o.s.) Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors.

Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal.

Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area.

Large spills: dike far ahead of spill for later disposal. (EPA, 1998)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Signs and Symptoms of Aminopterin Exposure: Signs and symptoms of acute exposure to aminopterin may include nausea, vomiting, anorexia, stomatitis (inflammation of the oral mucosa), pharyngitis (inflammation of the pharynx), erythematous rashes (red rashes on the skin), hyperpigmentation (abnormally increased pigmentation), chills, fever, gastrointestinal hemorrhage, and renal failure (especially in high doses). May induce abortion in pregnant women.

Emergency Life-Support Procedures: Acute exposure to aminopterin may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to aminopterin.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
4. Transport to a health care facility.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to aminopterin.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas thoroughly with water.
6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
7. Transport to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support to all victims.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of aminopterin is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4. Ipecac should not be administered to children under 6 months of age.Warning: Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Repeated oral charcoal doses may enhance total body clearance and elimination. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. A saline cathartic or sorbitol may be given with the first charcoal dose.
6. Transport to a health care facility. (EPA, 1998)

• 4-AMINO-4-DEOXYPTEROYLGLUTAMATE
• 4-AMINO-PGA
• 4-AMINOFOLIC ACID
• 4-AMINOPTEROYLGLUTAMIC ACID
• A-NINOPTERIN
• AMINOPTERIDINE
• AMINOPTERINE
• APGA
• ENT-26079
• FOLIC ACID, 4-AMINO-
• GLUTAMIC ACID, N-(P-(((2,4-DIAMINO-6-PTERIDINYL)METHYL)AMINO)BENZOYL)-, L-
• GLUTAMIC ACID, N-[P-[[(2,4-DIAMINO-6-PTERIDINYL)METHYL]AMINO]BENZOYL]-, L-
• L-GLUTAMIC ACID, N-[4-[(DIAMINO-6-PTERIDINYL)METHYL] AMINO]BENZOYL]-
• N-(4-((2,4-DIAMINO-6- PTERIDINYL)METHYL)AMINO)BENZOYL)-L-GLUTAMIC ACID
• NSC 739
• PTERAMINA