4-HYDROXYACETANILIDE

PHYSICAL DESCRIPTION: Odorless white crystalline solid. Bitter taste. pH (saturated aqueous solution) about 6. (NTP, 1992)

none

Slightly soluble in water.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

SYMPTOMS: Symptoms of overexposure to this compound include nausea, vomiting, cyanosis from methemoglobinemia, injury to the liver, kidneys, central nervous system and heart, circulatory collapse, drowsiness, confusion, liver tenderness, low blood pressure, cardiac arrhythmias, jaundice, acute renal failure, death due to liver necrosis, metabolic acidosis, hepatic damage and cirrhosis. Other symptoms include changes in exocrine pancreas, diarrhea, irritability, somnolence, general anesthesia, fever and hepatitis. Diaphoresis and general malaise may occur. Exposure may lead to hematological reactions and, occasionally, skin rashes and other allergic reactions. The rash is usually erythematous or urticarial, but sometimes it is more serious and may be accompanied by drug fever and mucosal lesions. Exposure to large amounts may lead to pallor, anorexia, abdominal pain, abnormalities of glucose metabolism and hepatic encephalopathy. It may also lead to epigastric pain, sweating, paresthesias of distal extremities, muscular aching, weakness, dizziness, central nervous system depression (rare), pain in the upper right quadrant, enlarged liver, oliguria, anuria, coagulation defects and myocardiopathy characterized by ST segment abnormalities, T-wave flattening and pericarditis. This compound can cause purpura, generalized bleeding and hypoglycemia. It can also cause neutropenia, pancytopenia, leukopenia, thrombocytopenia and nephrotoxicity. Other symptoms may include wheezing, general discomfort, blood changes including many anemias (aplastic anemia), central nervous system stimulation, swollen tongue, rapid pulse, skin eruptions, chills, excitement, delirium, vascular collapse and convulsions. Irritation of the skin, eyes, mucous membranes and upper respiratory tract may occur.

ACUTE/CHRONIC HAZARDS: This compound may be harmful by ingestion and inhalation. It may cause irritation of the skin, eyes, mucous membranes and upper respiratory tract. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. (NTP, 1992)

4-HYDROXYACETANILIDE is sensitive to light. Incompatible with strong oxidizers. (NTP, 1992).

• Amides and Imides
• Phenols and Cresols

No information available.

No information available.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this material from exposure to light. Keep it away from oxidizing materials and store it under ambient temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

• ABENSANIL
• ACAMOL
• ACENOL
• ACENOL (PHARMACEUTICAL)
• ACETAGESIC
• ACETALGIN
• ACETAMIDE, N-(4-HYDROXYPHENYL)-
• ACETAMIDE, N-(P-HYDROXYPHENYL)-
• 4-ACETAMIDOPHENOL
• ACETAMINOFEN
• ACETAMINOPHEN
• 4-ACETAMINOPHENOL
• ACETANILIDE, 4'-HYDROXY-
• 4-(ACETYLAMINO)PHENOL
• ALGOTROPYL
• ALPINYL
• ALVEDON
• AMADIL
• ANAFLON
• ANELIX
• ANHIBA
• APADON
• APAMID
• APAMIDE
• APAP
• BEN-U-RON
• BICKIE-MOL
• BIOCETAMOL
• CALPOL
• CETADOL
• CLIXODYNE
• CROCIN
• DATRIL
• DIAL-A-GESIC
• DIROX
• DOLIPRANE
• DUOROL
• DYMADON
• ENELFA
• ENERIL
• EXDOL
• FEBRILIX
• FEBRO-GESIC
• FEBROLIN
• FENDON
• FEPANIL
• FINIMAL
• G 1
• GELOCATIL
• HEDEX
• HOMOOLAN
• 4'-HYDROXYACETANILIDE
• 4-HYDROXYACETANILIDE
• JANUPAP
• KORUM
• LESTEMP
• LIQUAGESIC
• LONARID
• LYTECA
• LYTECA SYRUP
• MOMENTUM
• MULTIN
• N-(4-HYDROXYPHENYL)ACETAMIDE
• N-(P-HYDROXYPHENYL)ACETAMIDE
• N-ACETYL-4-AMINOPHENOL
• N-ACETYL-4-HYDROXYANILINE
• N-ACETYL-P-AMINOPHENOL
• 4-(N-ACETYLAMINO)PHENOL
• NAPA
• NAPA (ANALGESIC)
• NAPAFEN
• NAPAP
• NAPRINOL
• NCI-C55801
• NOBEDON
• P-(ACETYLAMINO)PHENOL
• P-ACETAMIDOPHENOL
• P-ACETAMINOPHENOL
• P-ACETOAMINOPHEN
• P-ACETYLAMINOPHENOL
• P-HYDROXYACETANILIDE
• PACEMO
• PANADOL
• PANETS
• PANEX
• PANOFEN
• PARACETAMOL
• PARACETAMOL DC
• PARACETAMOLE
• PARACETANOL
• PARALEN
• PARAPAN
• PARASPEN
• PARMOL
• PEDRIC
• PHENDON
• PHENOL, P-ACETAMIDO-
• PYRINAZINE
• SK-APAP
• TABALGIN
• TAPAR
• TEMLO
• TEMPANAL
• TEMPRA
• TRALGON
• TUSSAPAP
• TYLENOL
• VALADOL
• VALGESIC